浙江中西医结合杂志

胡康,叶美玉,李赛,王爽爽,季聪华,罗宏宾,刘姗.梅花针结合中药治疗斑秃的Meta分析[J].浙江中西医结合杂志,2019,29(1):

梅花针结合中药治疗斑秃的Meta分析

Meta analysis of plum-blossom needle combined with traditional Chinese medicine in the treatment of alopecia areata

投稿时间：2018-06-01 修订日期：2018-07-13

DOI：

英文关键词:plum-blossom needle alopecia areata Meta analysis systematic review

基金项目:浙江省中医药科技计划项目（No.2016ZA084）

作者	单位	E-mail
胡康	浙江中医药大学	zzdhukang@gmail.com
叶美玉	浙江中医药大学
李赛	浙江中医药大学
王爽爽	浙江中医药大学
季聪华	浙江省中医院
罗宏宾	浙江省中医院
刘姗^*	浙江省中医院	graystar92@163.com

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中文摘要:

目的：系统评价梅花针结合中药治疗斑秃的临床疗效和安全性。方法：通过计算机检索 PubMed、The Cochrane Library、CBM、CNKI、WanFang Data 数据库中梅花针治疗斑秃的随机对照试验（RCT）。由2位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险，采用Review Manager 5.3软件进行统计分析。结果：共纳入10篇文献，包括981例斑秃患者。Meta分析结果显示：与对照组相比，梅花针结合中药组能提高临床疗效[RR=1.17，95%CI（1.10，1.24），P＜0.001]，但皮损评分[SMD=-0.25，95%CI(-1.35，0.85)，P=0.65]和生活质量评分[SMD=-0.57，95%CI(-1.57，0.43)，P=0.26]两组的差异无统计学意义。安全性方面，针药结合组出现不良反应6例，对照组出现9例，Meta分析结果显示，两组发生不良反应差异无统计学意义[RR=0.66，95%CI（0.26，1.71），P=0.39]。结论：梅花针结合中药治疗斑秃优于常规用药组。由于纳入研究的文献数量有限，且文献质量普遍不高，上述结论仍需大型、多中心的RCT进一步验证。

英文摘要:

Objective: To systematically evaluate the clinical efficacy and safety of plum-blossom needle combined with traditional Chinese medicine in the treatment of alopecia areata. Methods: We searched PubMed, the Cochrane Library, CBM, CNKI and WanFang database for randomized controlled trials of plum-blossom needle in treating alopecia areata. Two researchers screened the literature, extracted data and evaluated the bias risk independently. The Review Manager 5.3 software was used for statistical analysis. Results: A total of 10 studies involving 981 patients were finally included. The Meta analysis results showed that there were statistical differences in clinical efficacy (RR=1.18, 95%CI (1.13, 1.24), P < 0.001), between the treatment group and control group, and the treatment group is superior to the control group. But there were no statistical differences in lesion score [SMD=-0.25, 95%CI (-1.35, 0.85), P=0.65] and quality of life score [SMD=-0.57, 95%CI (-1.57, 0.43), P=0.26]. For adverse reactions cases, there was no significant difference between two groups (RR=0.66, 95%CI (0.26, 1.71), P=0.39). Conclusion: The plum-blossom needle combined with Chinese medicine group on improving the symptoms of AA may be superior to the control group. Due to the small quantity and low quality of the included research, the conclusion still needs large, multi-center RCTs to verify.

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