| 俞欢,费煜畅,陈培丰.参芪扶正注射液治疗晚期非小细胞肺癌化疗后骨髓抑制的Meta分析[J].浙江中西医结合杂志,2019,29(3): |
| 参芪扶正注射液治疗晚期非小细胞肺癌化疗后骨髓抑制的Meta分析 |
| Meta-analysis of Shenqi Fuzheng Injection in Treating Advanced Non-small Cell Lung Cancer with Bone Marrow Suppression after Chemotherapy |
| 投稿时间：2018-05-27 修订日期：2019-01-28 |
| DOI： |
| 中文关键词: 参芪扶正 晚期非小细胞肺癌 骨髓抑制 Meta |
| 英文关键词:Shenqi Fuzheng Advanced Non-small Cell Lung Cancer Myelosuppression Meta |
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| 中文摘要: |
| 目的 通过Meta分析，系统评价参芪扶正注射液在治疗晚期非小细胞肺癌化疗后骨髓抑制的作用。方法 通过检索CNKI、Pubmed、Wan Fang Data、The Cochrane Library等数据库，根据纳入和排除标准筛选文献，采用Cochrane风险偏倚评估工具进行文献质量评价，并使用RevMan5.3软件进行统计学分析。结果 最终纳入11项研究，共包括967例患者。统计分析结果显示，化疗后试验组WBC、Hb、PLT减少的患者显著低于对照组，差异有统计学意义（P<0.05），试验组骨髓抑制程度低于对照组。结论 分析结果显示参芪扶正注射液可显著改善晚期非小细胞肺癌化疗后骨髓抑制，但由于纳入文献质量不高，还需要大量高质量、大样本的的随机对照试验来证实。 |
| 英文摘要: |
| Objective To systematically evaluate the effect of Shenqi Fuzheng Injection on myelosuppression after chemotherapy in patients with advanced non-small cell lung cancer. Methods By searching CNKI, Pubmed, Wan Fang Data, The Cochrane Library and other databases, the literature was screened according to the inclusion and exclusion criteria, the Cochrane risk bias assessment tool was used to evaluate the literature quality, and the RevMan 5.3 software was used for statistical analysis. Results Twelve studies were eventually included, including a total of 1057 patients. The statistical analysis showed that the patients with WBC, Hb, and PLT decrease in the experimental group after chemotherapy were significantly lower than those in the control group (P<0.05). The bone marrow suppression in the experimental group was lower than that in the control group. Conclusion The results of the analysis show that Shenqi Fuzheng Injection can significantly improve bone marrow suppression in patients with advanced non-small cell lung cancer after chemotherapy. However, due to the low quality of the included literature, a large number of high-quality, large-sample randomized controlled trials are needed to confirm this. |
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