| 朱之青,江荣林,楼屹,吴力,葛丹霞.宣白承气汤治疗热毒内盛型肺炎相关性脓毒症疗效观察*[J].浙江中西医结合杂志,2019,29(4): |
| 宣白承气汤治疗热毒内盛型肺炎相关性脓毒症疗效观察* |
| Observation on curative effect of Toxic heat Pneumonia correlation sepsis syndromes with Xuanbai Chengqi Decoction |
| 投稿时间：2018-04-18 修订日期：2019-02-22 |
| DOI： |
| 中文关键词: 宣白承气汤 热毒内盛 肺炎相关性脓毒症 |
| 英文关键词:Xuanbai Chengqi Decoction Toxic heat Pneumonia correlation sepsis syndromes |
| 基金项目:(81774070) 国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 【】：目的：观察宣白承气汤治疗热毒内盛型肺炎相关性脓毒症临床疗效。方法：将60例肺炎相关性脓毒症患者随机分为对照组和宣白承气汤组各30例,两组均予西医常规治疗,宣白承气汤组在此基础上加用宣白承气汤加减。观察两组治疗第3、7天血气分析中氧分压(PaO2)、氧合指数(OI)、乳酸(Lac)及C-反应蛋白(CRP)、降钙素原(PCT)等炎症指标变化,同时比较两组治疗后急性生理与慢性健康评分(APACHEII评分)、全身性感染相关性器官功能衰竭评分(SOFA评分)、临床肺部感染评分(CPIS评分)及重症医学科(ICU)住院时间、28天病死率。结果：两组于治疗第3、7天的OI、Lac均有所好转,CRP、PCT及APACHEII、SOFA、CPIS评分均有所下降,且于第7天的上述指标宣白承气汤组较对照组明显改善,差异均有统计学意义(P＜0.05),宣白承气汤组的ICU住院时间、28天病死率均较对照组低,差异均有统计学意义(P＜0.05)。结论：对热毒内盛型肺炎相关性脓毒症患者应用宣白承气汤有助于提高肺的氧合功能,减轻炎症反应,保护器官功能,从而改善预后。 |
| 英文摘要: |
| Objective：To observe the clinical efficacy of Xuanbai Chengqi Decoction in the treatment of Toxic heat Pneumonia correlation sepsis syndromes.
Methods: Sixty patients with Pneumonia correlation sepsis syndrome were randomly divided into control group and Xuanbai Chengqi Decoction group (n = 30). Both groups were treated routinely with Western medicine. Xuanbai Chengqi Decoction group was added and subtracted based on the above results. PaO2, OI, Lac and CRP, PCT and other inflammatory markers in the two groups were observed on the 3rd and 7th day after treatment. APACHEII score, SOFA score, CPIS score, ICU stay time and 28d mortality rate were compared between the two groups.
Results: Blood gas indicators on the 3rd and 7th day of Xuanbai Chengqi Decoction group improved compared with that of the control group, the difference was statistically significant on the 7th day (P <0.05), inflammation indicators and organ function score also decreased compared with the control group, ICU hospitalization time was shortened, 28d mortality decreased, the differences were statistically significant (P <0.05).
Conclusion: Application of Xuanbai Chengqi Decoction to patients with Toxic heat Pneumonia correlation sepsis syndrome can improve oxygenation, reduce inflammation and protect organ function so as to improve prognosis. |
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