| 杨倩倩,周建波,蔡升,方莹.白术芍药散联合美沙拉嗪治疗溃疡性结肠炎的疗效及对NGAL、MMP-9的影响[J].浙江中西医结合杂志,2018,28(12): |
| 白术芍药散联合美沙拉嗪治疗溃疡性结肠炎的疗效及对NGAL、MMP-9的影响 |
| Clinical effect of baizhushaoyao powder combined with mesalazine in the treatment of ulcerative colitis and the influence of NGAL, MMP-9 |
| 投稿时间：2018-03-21 修订日期：2018-10-02 |
| DOI： |
| 中文关键词: 白术芍药散 溃疡性结肠炎 效果 NGAL MMP-9 |
| 英文关键词:baizhushaoyao powder, ulcerative colitis, curative effect, NGAL, MMP-9 |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨白术芍药散联合美沙拉嗪治疗溃疡性结肠炎(ulcerative colitis, UC)的临床疗效及对中性粒细胞明胶酶相关载脂蛋白(NGAL)、基质金属蛋白酶9(MMP-9)的影响。方法：选取UC患者80例,随机分为观察组和对照组。对照组给予美沙拉嗪1.0g qid,观察组在对照组基础上联合白术芍药散汤剂 bid。疗程共8周。比较两组的治疗效果；采用实时荧光定量PCR法(RT-PCR)检测肠黏膜中NGAL、MMP-9 mRNA表达水平；采用酶联免疫吸附法(ELISA)检测血清中NGAL、MMP-9 蛋白表达水平。结果：经治疗后,观察组的临床症状改善总有效率(85.00%)显著优于对照组(70.00%),差异有统计学意义(P<0.05)。 |
| 英文摘要: |
| Objective: To investigate the Clinical effect of baizhushaoyao powder combined with mesalazine in the treatment of ulcerative colitis(UC) and the influence of neutrophil gelatinase-associated lipocalin(NGAL) and matrix metalloproteinase-9(MMP-9). Methods: 80 patients with UC were randomly divided into Control group and Observation group, 50 cases in each group. Control group was given mesalazine 1.0g Qid, Observation group was given baizhushaoyao powder Bid combined with mesalazine 1.0g qid. The course of treatment was 8 weeks. The clinical efficacy of the two groups was compared; The expression levels of NGAL, MMP-9 mRNA were detected by realtime fluorescence quantitative Polymerase ChainReaction(RT-PCR); The levels of NGAL, MMP-9 in serum was detected by Enzyme linked immunosorbent assay (ELISA). Results: After treatment, the total effective rate of the clinical symptoms of Observation group (85%) was significantly better than that of Control group (70%), the difference was statistically significant (P<0.05). The expression of NGAL, MMP-9 mRNA in Observation group (0.44±0.09, 0.39±0.09) was more lower than that of Control group (0.63±0.12, 0.55±0.11), and the difference was statistically significant (P<0.05). |
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