| 曹杨荣.经支气管镜冷冻治疗支气管结核的临床疗效及对炎性因子的影响[J].浙江中西医结合杂志,2018,28(12): |
| 经支气管镜冷冻治疗支气管结核的临床疗效及对炎性因子的影响 |
| Clinical effect and inflammatory cytokines on Bronchoscopic cryotherapy for the treatment of bronchial tuberculosisDepartment of tuberculosis Cao Yangrong Jinhua Guangfu hospital 321000 |
| 投稿时间：2018-03-02 修订日期：2018-04-19 |
| DOI： |
| 中文关键词: 支气管结核 支气管镜 临床疗效 炎性因子 |
| 英文关键词:Bronchial tuberculosis Bronchoscopy Clinical efficacy Inflammatory factors |
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| 中文摘要: |
| 【】 目的 常规抗结核药物联合经支气管镜冷冻治疗支气管结核,观察其临床疗效、安全性,并评估对患者炎性因子的影响。方法 选择本院2016年1月～2017年9月的支气管结核患者患者78例,随机分为对照组(39例)和治疗组(39例),对照组行常规治疗并雾化吸入异烟肼。治疗组在常规治疗基础上应用支气管镜冷冻治疗。观察其临床疗效、不良反应,治疗前后评估患者第1秒用力呼气量(FEV1)、气促评分,检测患者外周血C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)水平。结果 治疗组总有效率为71.79%(28/39),高于对照组56.41%(22/39),差异具有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P＞0.05)。治疗组患者治疗后FEV1为(1.86±0.26)L,高于对照组(1.64±0.33)L,治疗组治疗后气促评分、血清CRP和TNF-α分别为(1.51±0.16)分、(10.41±2.80)mg/L和(105.62±22.81)pg/ml,均低于对照组(2.70±0.19)分、(13.69±2.74)mg/L和(139.35±23.46)pg/ml,差异有统计学意义(P＜0.05)。结论 常规抗结核药物联合经支气管镜冷冻治疗支气管结核,临床疗效显著,炎性因子水平下降,肺部功能和呼吸状况显著改善,并具有较好的安全性。 |
| 英文摘要: |
| objective Conventional anti-tuberculosis drugs combined with bronchoscopic bronchoscopy for the treatment of bronchial tuberculosis, to observe its clinical efficacy, safety, and evaluation of the impact of inflammatory factors.Methods 78 patients with bronchial tuberculosis from January in 2016 to September in 2017 in our hospital were randomly divided into control group (39 cases) and treatment group (39 cases). Patients in control group were treated with conventional anti-tuberculosis drugs and inhaled inhalation of isoniazid. The treatment group was treated with bronchoscopy on the basis of routine treatment. The clinical efficacy and adverse reactions were observed. The forced expiratory volume per second (FEV1), shortness of breath, and the levels of C-reactive protein (CRP), tumor necrosis factor (TNF-α) were measured before and after treatment. Results The total effective rate of the treatment group was 71.79% (28/39), which was higher than that of the control group 56.41%(22/39). The difference was statistically significant (P<0.05). Adverse reactions compared between two groups, the difference was not statistically significant (P>0.05). FEV1 of treatment group after treatment was (1.86±0.26) L, which was significantly higher than that of control group (1.64 ± 0.33) L. After treatment, the scores of shortness of breath and serum CRP and TNF-α of treatment group were (1.51 ± 0.16) points, (10.41±2.80)mg/L and (105.62±22.81)pg/ml, lower than those of control group (2.70±0.19)points, (13.69±2.74) mg/L and (139.35±23.46) pg/ml, respectively,the differences were statistically significant (P<0.05).Conclusion The application of conventional anti-tuberculosis drugs combined with bronchoscopic bronchoscopy for the treatment of bronchial tuberculosis, the clinical significant effect is better, levels of inflammatory cytokines decreased, lung function and respiratory status significantly improved, and has good safety.. |
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