| 雷梅花.银杏内酯对高危非致残性缺血性脑血管病患者的疗效及相关血液因子的影响[J].浙江中西医结合杂志,2019,29(1): |
| 银杏内酯对高危非致残性缺血性脑血管病患者的疗效及相关血液因子的影响 |
| The clinic effect and blood factor of ginkgolide on patients with high risk of high-risk non-disabling ischemic cerebrovascular events |
| 投稿时间：2018-02-01 修订日期：2018-04-03 |
| DOI： |
| 中文关键词: 银杏内酯注射液 高危非致残性缺血性脑血管病（HR-NICE） 临床疗效 脂蛋白磷脂酶A2(Lp-PLA2) 神经元特异性烯醇化酶(NSE) 神经胶质纤维酸性蛋白(GFAP) |
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| 中文摘要: |
| 目的 探讨应用银杏内酯注射液对高危非致残性缺血性脑血管病（HR-NICE）患者的临床疗效及神经功能缺损的保护作用，并评估对血脂蛋白磷脂酶A2(Lp-PLA2)、神经元特异性烯醇化酶(NSE)和神经胶质纤维酸性蛋白(GFAP)的影响，为临床HR-NICE的防治提供依据。方法 选择本院2016年1月～2017年6月HR-NICE患者144例，采用随机数字表法将患者随机分为对照组和治疗组，各72例，对照组进行常规治疗，治疗组在常规基础上应用银杏内酯注射液治疗。评估临床疗效，神经改善状况、预后，并检测血Lp-PLA2、NSE、GFAP水平。结果治疗组患者总有效率为86.11%（62/72），高于对照组75.00%（54/72），治疗组终点事件发生率为5.56%（4/72），低于对照组15.28%（11/72），差异有统计学意义( P＜0.05)；治疗组治疗后NIHSS评分、血清Lp-PLA2、NSE、GFAP分别为（0.81±0.34）分、（163.04±19.85）μg/L、（7.24±0.38）μg/L、（0.71±0.20）ng/L，均低于对照组（1.30±0.41）分、（187.39±21.40）μg/L、（10.90±0.41μg/L、（1.08±0.19）ng/L，差异有统计学意义(P＜0.05)。结论 应用银杏内酯注射液治疗HR-NICE患者疗效显著，患者神经功能缺损与预后显著改善，血Lp-PLA2、NSE、GFAP水平下降，值得临床推广应用。 |
| 英文摘要: |
| Objective To explore the clinical efficacy and nerve function protective effect of ginkgolide injection on high-risk non disabling ischemic cerebrovascular disease (HR-NICE) patients, and to evaluate the effect of ginkgolide on blood Lipid protein phospholipase A2 (Lp-PLA2), neuron specific enolase (NSE) and glial fibrillary acidic protein (GFAP),to provide evidence for the prevention and treatment of HR-NICE.Methods 144 patients with HR-NICE in our hospital from January in 2016 to June in 2017 were selected and randomly divided into the control group and the treatment group by random number table method, 72 cases in each group. The control group received routine treatment, while the treatment group was given ginkgolide injection on the regular basis.Assessed the clinical efficacy, neurological improvement, prognosis, and blood Lp-PLA2, NSE, GFAP levels were measured.Results The total effective rate of the treatment group was 86.11% (62/72), which was higher than that of the control group 75% (54/72),the incidence of the end point events of the treatment group was 5.56% (4/72), which was lower than that of the control group 15.28% (11/72), the difference was statistically significant (P<0.05).After treatment, NIHSS score, serum Lp-PLA2, NSE, GFAP of the treatment group respectively (0.81±0.34), (163.04±19.85) g/L, (7.24 ±0.38) g/L and (0.71±0.20) ng/L, were lower than the control group (1.30±0.41) points and (187.39±21.40) g/L, (10.90±0.41)g/L and (1.08±0.19) ng/L, the difference was statistically significant (P < 0.05). Conclusion Ginkgolide injection is effective for the treatment of HR-NICE. The neurological deficit and prognosis of patients are significantly improved, and the levels of Lp-PLA2, NSE and GFAP decrease. It is worthy of clinical application. |
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