浙江中西医结合杂志

魏惠亚,邵启民,陈捷,贾黎红.2016年杭州儿童医院支气管肺炎住院患儿呼吸道感染病原学特征[J].浙江中西医结合杂志,2018,28(10):

2016年杭州儿童医院支气管肺炎住院患儿呼吸道感染病原学特征

Etiologic characteristics of hospitalized children with bronchopneumonia in one hospital in 2016

投稿时间：2018-01-04 修订日期：2018-04-19

DOI：

英文关键词:epidemiological characteristics etiology respiratory tract infection bronchopneumonia children

基金项目:

作者	单位	E-mail
魏惠亚^*	杭州市儿童医院	chutianyaya@126.com
邵启民	杭州市儿童医院
陈捷	杭州市儿童医院
贾黎红	杭州市儿童医院

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中文摘要:

目的：了解杭州市儿童呼吸道感染病原学的流行特征。方法：选取2016年杭州市儿童医院支气管肺炎住院患儿间接免疫荧光法测定的呼吸道病原体IgM抗体结果进行分析。结果：最常见病原依次肺炎支原体MP（20.72%），流感病毒B型INFB（15.03%），流感病毒A型INFA（7.05%），副流感病毒PIV（5.47%），呼吸道合胞病毒RSV（3.99%）。病原检出率7y～14y最高（94.92%），1m～1y最低（21.28%），年龄段之间差异均有统计学意义（P<0.05）。1m～1y最常见RSV、MP（?2=0.619,P=0.431）。1～3y、3～7y、7y～14y年龄段均最常见MP，其次INFB，但同年龄段MP和INFB差异有统计学意义（依次分别为?2=5.931，P=0.015；?2=6.176，P=0.013；?2=13.475，P=0.000），且各年龄段之间MP（?2=16.452，P=0.000）和INFB（?2=38.142,P=0.000）各自差异有统计学意义。各月病原检出率依次10、11、9月最高（?2=1.974,P=0.370），5、8、7月最低（?2=0.955,P=0.624），各自差异无统计学意义。3-11月MP检出率最高，其次INFB，两者差异有统计学意义（?2=27.450，P=0.000），且在各月之间MP（?2=30.849，P=0.000）和INFB（?2=62.776，P=0.000）各自差异有统计学意义，MP夏秋季节（6-11月）高，INFB秋冬季节(1-2、9-12月)高。此外，RSV、INFA、PIV均为秋冬季节高。结论：常见呼吸道病原依次MP、INFB、INFA、PIV，MP趋于小龄化，婴儿及低龄儿童是肺炎防治重点人群，建议适龄儿童每年接种相关疫苗，临床应结合年龄、季节等进行综合判断病原并及早检测。

英文摘要:

[Abstract] Objective: To find out the epidemiological characteristics of pathogens of respiratory tract infections in children in Hangzhou. Methods: Analysis the respiratory pathogens’ IgM antibody in children hospitalized with bronchopneumonia in Hangzhou Children's Hospital in 2016 by indirect immunofluorescence method. Results: The most common pathogens were MP (20.72%), INFB (15.03%), INFA (7.05%), PIV (5.47%), and RSV (3.99%). The positive detection rate of pathogens was highest in 7y～(94.92%), lowest in 1m～1y (21.28%), and the difference was statistically significant(P<0.05). In 1m～1y, the most common pathogens are RSV and MP (?2=0.619, P=0.431). In 1～3y、3～7y、7y～the most common pathogens are MP, followed by INFB, but the difference between MP and INFB in the same age group was statistically significant (successively ?2=5.931，P=0.015；?2=6.176，P=0.013；?2=13.475，P=0.000). And the differences were also statistically significant among different age groups in MP (?2=16.452，P=0.000) and INFB (?2=38.142, P=0.000). The positive detection rates of pathogens in each month found to be the highest in October, November and September (?2=1.974, P=0.370), and the lowest in May, August and July（?2=0.955, P=0.624）, the difference was not statistically significant in each group. From March to November, the positive detection rate of MP was the highest, followed by INFB, the difference between these two pathogens was statistically significant（?2=27.450，P=0.000）. And between months, MP（?2=30.849，P=0.000）or INFB（?2=62.776，P=0.000）was statistically different. MP is higher in summer and autumn (June to November), INFB is higher in autumn and winter (January, February, September to December). In addition, RSV, INFA and PIV are all higher in autumn and winter. Conclusion: The common respiratory pathogens successively MP, INFB, INFA, PIV, MP tend to be found in younger age. Infants and young children are the key population for prevention and treatment of pneumonia. Vaccination is recommended for children of appropriate age each year, and comprehensive recognization and early test should be taken basing on age, season and so on.

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