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谢明斌.正常范围内甲状腺功能的变化与冠状动脉粥样硬化严重程度的相关性研究[J].浙江中西医结合杂志,2018,28(8):
正常范围内甲状腺功能的变化与冠状动脉粥样硬化严重程度的相关性研究
Thyroid function within the statistical normal range is associated with the severity of coronary atherosclerosis
投稿时间:2018-01-04  修订日期:2018-04-17
DOI:
中文关键词:  甲状腺功能正常范围内改变  冠心病  SYNTAX积分
英文关键词:Thyroid function within the statistical normal range  coronary heart disease  SYNTAX score
基金项目:
作者单位E-mail
谢明斌 杭州市红十字会医院 xiemingbin194@126.com 
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中文摘要:
      目的:探讨甲状腺功能在正常范围内的变化是否会影响冠状动脉粥样硬化的发生以及严重性。方法:我们入选了100位行冠脉造影检查的患者(62位男性,38位女性,平均60.98±8.5岁),根据造影结果计算SYNTAX积分评估冠脉严重程度,分成轻危组(0-22分)、中危组(23-32分)及高危组(≥33分),所有患者均抽血查甲状腺功能、血糖及血脂等。结果:冠脉病变高危组游离T3(FT3)水平为2.48±0.22 pg/ml,显著低于冠脉病变低危组(3.02±0.2 pg/ml,P<0.05)及冠脉病变中危组(2.67±0.17 pg/ml,P<0.05)。FT3水平与SNYTAX积分呈显著性负相关,相关系数为-0.726(P<0.05)。结论:甲状腺功能即使在检验正常范围内的变化也将影响冠状动脉粥样硬化的发生及严重性,FT3水平越低冠脉病变越严重。
英文摘要:
      Objective: To evaluate whether the variation of thyroid function within the normal range may influence the severity of coronary atherosclerosis. Methods:We studied a total of 100 patients (62men, 38 women, age 60.98±8.5 years) who underwent coronary angiography. We evaluated the severity of coronary atherosclerosis using SYNTAX score. Then patients were divided into low risk group (0-22), moderate risk group(23-32), and high risk group(≥33). Blood was tested for serum biochemical and thyroid function. Results: The level of FT3 in the high risk group is 2.48±0.22 pg/ml, significantly decreased when compared with the low risk group(3.02±0.2 pg/ml,P<0.05), and the moderate risk group(2.67±0.17 pg/ml,P<0.05). Furthermore, The correlation analysis showed the significant negative correlation of the level of FT3 and the SNYTAX score(r=-0.726, P<0.05). Conclusion: This study suggest that variation of thyroid function within the statistical normal range may influence the severity of coronary atherosclerosis. The lower the level of FT3, the more severe coronary atherosclerosis.
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