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蔡田恬,赵敏,王建平.PI3K抑制剂的研究进展[J].浙江中西医结合杂志,2018,28(8):
PI3K抑制剂的研究进展
Research progress of PI3K InhibitorsCai Tiantian1 Zhao Ming2 Wang Jianping2*(1.2.The First Affiliated Hospital of Zhejiang Chinese Medical University,ZhejiangHangzhou 310006)
投稿时间:2017-07-19  修订日期:2018-06-05
DOI:
中文关键词:  PI3K,PI3K-Akt-mTOR通路,肿瘤,PI3K抑制剂
英文关键词:PI3K,PI3K-Akt-mTOR  pathway,tumor,PI3K  inhibitors
基金项目:
作者单位E-mail
蔡田恬 浙江省中医院 786051895@qq.com 
赵敏 浙江省中医院  
王建平 浙江省中医院 jim917@163.com 
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中文摘要:
      PI3K作为一种胞内磷脂酰肌醇激酶,是细胞内重要的信号转导分子,参与调节细胞的增殖、凋亡与分化等生理过程。众多研究表明PI3K依赖性信号通路(以PI3K-Akt-mTOR通路为主)的过度激活与肿瘤的发生有密切关系。过去的几十年中以PI3K-Akt-mTOR通路为靶点的治疗已经取得了很大进步,使得人们认识到PI3K抑制剂在肿瘤的治疗中发挥的重要作用。本文将对PI3K抑制剂在抗肿瘤方面的研究进展作一综述。
英文摘要:
      PI3K, an intracellular phosphatidylinositol kinase, plays an important role in the regulation of cell proliferation, apoptosis and differentiation. Numerous studies have shown that the excessive activation of PI3K-dependent signaling pathway (mainly PI3K-Akt-mTOR pathway) is closely related to tumorigenesis. The treatment targeting PI3K-Akt-mTOR pathway has made great progress in the past several decades, and it has been recognized that PI3K inhibitors play an important role in tumor therapy. In this paper, the progress of PI3K inhibitors in anti-tumor research is reviewed.
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