| 章宇明.腹腔镜切除术治疗老年T2期肾细胞癌对免疫功能及神经内分泌功能的影响[J].浙江中西医结合杂志,2018,28(2): |
| 腹腔镜切除术治疗老年T2期肾细胞癌对免疫功能及神经内分泌功能的影响 |
| Effects of laparoscopic resection on immune function and neuroendocrine function in elderly patients with T2 stage renal cell carcinoma |
| 投稿时间：2017-07-04 修订日期：2018-01-18 |
| DOI： |
| 中文关键词: 肾细胞癌 开放性根治性肾切除术 腹腔镜根治性肾切除术 |
| 英文关键词: |
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| 中文摘要: |
| 目的：比较腹腔镜和开放性根治性肾切除术治疗老年T2期肾癌后对免疫功能及神经内分泌功能的影响。方法：选取2013年2月～2015年2月来我院住院手术治疗的老年T2期肾癌患者作为观察对象,根据手术方式不同分为两组,对照组采取开放性根治性肾切除术,观察组采取腹腔镜根治性肾切除术,比较两组患者手术相关情况及术后免疫功能及神经内分泌功能的变化。结果：在手术时间的比较中,两组无显著性差异(P＞0.05),观察组较对照组术中失血量更少,肠道恢复时间更早,住院时间更短,差异有统计学意义(P＜0.05)。两组患者术前CD3+、CD4+、CD8+均无显著差异(P＞0.05),在术后1天、术后3天观察组CD3+、CD4+水平均高于对照组,CD8+水平均低于对照组,差异有统计学意义(P＜0.05)。两组患者β-内啡肽、皮质醇促肾上腺皮质激素水平术前均无显著差异(P＞0.05),在术后1天、术后3天观察组各项神经内分泌激素水平均低于对照组,差异有统计学意义(P＜0.05)。结论：腹腔镜根治性肾切除术治疗老年T2期肾癌较开放性根治性肾切除术创伤小、出血少、恢复快等优点,术后有助于免疫功能及神经内分泌功能的保护。 |
| 英文摘要: |
| Objective To compare the effects of laparoscopic and open radical nephrectomy on immune function and neuroendocrine function in elderly patients with T2 stage renal. Methods From February 2013 to February 2015, the elderly patients with T2 stage renal cell carcinoma who were hospitalized in our hospital were selected as the subjects. According to the different surgical methods, the rats in the control group were treated with open radical nephrectomy. The patients underwent laparoscopic radical nephrectomy, and the changes of the operation and the postoperative immune function and neuroendocrine function were compared between the two groups. Results There was no significant difference between the two groups (P> 0.05). In the observation group, the blood loss in the observation group was less than that in the control group, the intestinal recovery time was earlier and the hospitalization time was shorter, the difference was statistically significant (P <0.05). There was no significant difference in CD3 +, CD4 +, CD8 + between the two groups (P> 0.05). The levels of CD3 + and CD4 + in the observation group were higher than those in the control group at 1 day and 3 days after operation, The difference was statistically significant (P <0.05). There was no significant difference in the levels of β-endorphin and cortisol-induced adrenocorticotropic hormone between the two groups (P> 0.05). The levels of neuroendocrine hormones in the observation group were lower than those in the control group Group, the difference was statistically significant (P <0.05). Conclusion Laparoscopic radical nephrectomy is more effective in the treatment of neonatal T2 nephropathy than open radical nephrectomy, less bleeding and quick recovery. It is helpful to protect the immune function and neuroendocrine function after operation. |
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