| 蒋先明,文强,叶瑞智,刘丽丹.小边界适形调强放疗与指南边界适形调强放疗联合替莫唑胺化疗在脑恶性胶质瘤的应用及其相关因素的回顾性研究[J].浙江中西医结合杂志,2018,28(5): |
| 小边界适形调强放疗与指南边界适形调强放疗联合替莫唑胺化疗在脑恶性胶质瘤的应用及其相关因素的回顾性研究 |
| Retrospective study of small border limited margins intensity-modulated radiotherapy and guidelines limited margins combined with temozolomide chemotherapy for the treatment of patients with malignant glioma and study on the related factors |
| 投稿时间：2017-05-11 修订日期：2018-03-28 |
| DOI： |
| 中文关键词: 适形调强放疗 替莫唑胺 脑恶性胶质瘤 相关因素 |
| 英文关键词:Intensity-modulated radiotherapy Temozolomide Malignant glioma Related factors |
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| 中文摘要: |
| 目的：回顾性研究小边界与指南边界适形调强放疗联合替莫唑胺化疗在脑恶性胶质瘤的应用及其相关因素。方法：选取本院104例脑恶性胶质瘤患者，随机分为观察组行小边界适形调强放疗，对照组行指南边界适形调强放疗，两组各52例，放疗期间均联合替莫唑胺进行化疗，对比两组近期疗效、1年生存情况以及相关因素分析。结果：两组治疗总有效率对比并无明显差异（P>0.05）；两组1年平均无进展生存期、1年无进展生存率及1年生存率对比均无明显差异（P均>0.05）；手术情况与和MGMT甲基化状态均是近期疗效的影响因素（P均<0.05），而手术情况是1年平均无进展生存期的影响因素（P<0.05）。结论：小边界适形调强放疗与指南边界适形调强放疗联合替莫唑胺化疗在治疗脑恶性胶质瘤患者中的疗效相当，手术情况是其预后的重要影响因素。 |
| 英文摘要: |
| Objective To retrospectively study the application of small border and guidelines limited margins intensity-modulated radiotherapy combined with temozolomide chemotherapy for the treatment of patients with malignant glioma and its related factors. Methods 104 cases of malignant glioma were selected in our hospital, and were randomly divided into the observation group underwent small boundary limited margins intensity-modulated radiotherapy and the control group received guidelines limited margins intensity-modulated radiotherapy, with 52 cases in each group.104 cases were all treated with radiotherapy combined with temozolomide chemotherapy and the curative effects and survival situation of one year were compared between the two groups and the related factors were analyzed. Results The total efficiency of the two groups showed no significant difference (P>0.05); the progression free survival of 1 year, PFSR-1 and survival rate of 1 year showed no significant difference between the two groups (Pall>0.05); the surgery situation and MGMT methylation were influencing factors on the curative effects (P both<0.05), and the surgery situation was the influencing factors on progression free survival of 1 year (P<0.05). Conclusion Small border and guidelines limited margins intensity-modulated radiotherapy combined with temozolomide chemotherapy have similar effects in the treatment of patients with malignant glioma, and the surgery situation is an important influencing factor on the prognosis. |
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