| 吴旭萍,张海桥,林胜友.中医药对肺癌p53基因表达影响的研究进展[J].浙江中西医结合杂志,2018,28(5): |
| 中医药对肺癌p53基因表达影响的研究进展 |
| Research of traditional Chinese medicine on the expression of p53 gene in lung cancer |
| 投稿时间：2017-05-09 修订日期：2017-11-23 |
| DOI： |
| 中文关键词: 中医药,肺癌,p53基因,作用机制,综述 |
| 英文关键词:traditional Chinese medicine,lung cancer,p53 gene, mechanisms, overview |
| 基金项目:浙江省中医药科技计划一般项目(2017ZB078) |
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| 摘要点击次数: 744 |
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| 中文摘要: |
| 肿瘤抑制基因p53可诱导细胞凋亡、分化以及DNA 修复。突变型p53基因能促进细胞增殖、转化,并且具有致癌作用。故p53在肿瘤等疾病中起着重大的作用。本文对近年来中医药调节肺癌p53基因表达的影响的研究进行综述,研究表明中医药在一定程度上能够抑制突变型p53基因的表达,增强野生型p53基因的表达。中医药对肺癌p53基因表达的研究,对开发和研制抗肺癌新药具有指导作用,从而更好地治疗肿瘤。 |
| 英文摘要: |
| Tumor inhibition gene p53 can induces apoptosis, cell differentiation and DNA repair. Mutant p53 gene can advance cell proliferation, transformation, and be carcinogenic. Therefore, p53 gene plays an important role in cancer and other diseases. This article reviewed the effects of traditional Chinese medicine on the expression of p53 gene in lung cancer in recent years. Research shows that Chinese medicine can inhibit the expression of mutant p53 gene in a certain extent, enhancing the expression of wild type p53 gene. The study on the expression of p53 gene in lung cancer by traditional Chinese medicine has a guiding effect on the new drugs to treat lung cancer. |
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