| 舒祝明,施政,章建军,蔡田恬,沈 玮,王建平.中医药治疗痛风病人高尿酸血症临床疗效的荟萃分析[J].浙江中西医结合杂志,2017,27(5): |
| 中医药治疗痛风病人高尿酸血症临床疗效的荟萃分析 |
| The short-term effects of traditional Chinese medicine combined with western medicine in hyperuricemic patients: a meta-analysis of randomized trials |
| 投稿时间：2016-10-19 修订日期：2016-11-24 |
| DOI： |
| 中文关键词: 中医药 高尿酸血症 荟萃分析 |
| 英文关键词:Traditional Chinese medicine Hyperuricemia Meta-analysis |
| 基金项目: |
|
| 摘要点击次数: 835 |
| 全文下载次数: 5 |
| 中文摘要: |
| 目的 探讨中医药治疗痛风病人高尿酸血症的近期疗效。方法 通过Medline、Embase、Cochrane Library、中国生物医学文献数据库、中国期刊全文数据库、中文生物医学期刊文献数据库和数字化期刊全文数据库等数据库中检索已发表的关于中医药治疗高尿酸血症的随机对照临床试验研究,并由2名评价员按照Cochrane系统评价员手册要求对搜索到的文献进行筛选、评价、数据收集分析,并应用Jadad评分对入选文献进行评分。利用Review Manager 5.2.6软件(RevMan 5.2.6)对入选研究的近期疗效进行荟萃分析。结果 按入选标准,共纳入14个随机对照临床试验研究,涉及1 374例病例。荟萃分析表明：异质性检验P = 0.02,表明研究数据具有异质性,可用随机效应模型进行分析。中医药临床治疗高尿酸血症与单纯西医药比较,疗效的差异无统计学意义[RR值及95%CI、Z值和P值分别为1.03 (0.98~1.09),Z = 1.28,P = 0.20]。结论 目前掌握的研究结果显示,中医药治疗痛风病人高尿酸血症的近期临床疗效方面与西药对照组相当,不良反应发生率显著低于西药对照组,但仍需要严格设计的、大样本的随机对照试验来进一步验证和支持。 |
| 英文摘要: |
| Objective To evaluate the short-term effects of traditional Chinese medicine with western medicine therapy for hyperuricemic patients. Methods A comprehensive retrieval of the relevant literatures was performed by searching major biomedical database, Medline, Embase, the Cochrane Library, Chinese Biomedical Literature Database(CBM), China Academic Journals Full-text Database(CNKI), Chinese Medical Current Contents(CMCC) and China Online Journals (Wangfang). And study selection and assessment, data collection, and analysis were assessed via Jadad quality scale by two reviewers. Statistical analysis was performed using Review Manager Software 5.2.6 (RevMan 5.2.6). Results Overall, there were 14 studies of randomized controlled trials with 1 374 patients. All researches were heterogeneity (P = 0.02). The study was performed using a random-effects model. The results of this meta-analysis illustrated that short-term effects in hyperuricemic patients receiving traditional Chinese medicine were not significantly different from those receiving western medicine (RR = 1.03 [0.98, 1.09], Z = 1.28, P = 0.20). Conclusion The result of the study suggested traditional Chinese medicine shows curative effect, and not significantly different from those receiving western medicine, while the side reaction rate of treatment group was significantly lower than contrast group. Further large-scale multicentre and better designed study were still expected to give more convincing evidence. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
