| 杨盛娅,牟新,盛云峰,鲍志坚.降钙素原对COPD急性期患者非侵袭性正压通气的指导作用[J].浙江中西医结合杂志,2017,27(5): |
| 降钙素原对COPD急性期患者非侵袭性正压通气的指导作用 |
| Procalcitonin may act as a predictor of noninvasive positive pressure ventilation in acute chronic obstructive pulmonary disease exacerbation |
| 投稿时间：2016-10-17 修订日期：2016-11-26 |
| DOI： |
| 中文关键词: 降钙素原 COPD急性期 非侵袭性正压通气 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨炎性标志物在COPD急性期患者非侵袭性正压通气治疗中的临床意义。 方法 检测60例使用非侵袭性正压通气的COPD急性期患者(实验组)和同期100例未使用者(对照组)静脉血中CRP、WBC和PCT水平,并采用ROC曲线法进行灵敏度和特异度评价。 结果 实验组CRP、WBC和PCT水平显著高于对照组,PCT对是否使用非侵袭性正压通气具有良好的指导作用,其ROC曲线下面积为0.897(0.838-0.957),当临界值(诊断阈值)取0.12时,其灵敏度为0.85,特异度为0.86。 结论 PCT的灵敏度和特异度较高,可用于COPD急性加重期患者应用非侵袭性正压通气的指导指标。 |
| 英文摘要: |
| Objective To evaluate the clinical predicational effect of procalcitonin of noninvasive positive pressure ventilation in acute chronic obstructive pulmonary disease exacerbation. Methods Blood CRP、WBC and PCT level of 60 COPD exacerbation patients(case group) treated with noninvasive positive pressure ventilation and 100 cases of non-user(control group) in the same period were detected. Sensitivity and sepecificity were evaluated by ROC curve. Results the CRP, WBC and PCT levels in case group were significantly higher than control group. PCT is a good predictor of noninvasive positive pressure ventilation in acute chronic obstructive pulmonary disease exacerbation. The area under the ROC curve 0.897 (0.838-0.957), when the critical value (diagnostic threshold ) when taking 0.12, the sensitivity was 0.85 and specificity was 0.86. Conclusions With high sensitivity and specificity, PCT can be used as a predictor of noninvasive positive pressure ventilation in acute chronic obstructive pulmonary disease exacerbation. |
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