| 邓琳,贾亚利,陈健,吴黎明.别嘌醇致药物超敏反应综合征4例并文献复习[J].浙江中西医结合杂志,2017,27(5): |
| 别嘌醇致药物超敏反应综合征4例并文献复习 |
| Drug Hypersensitivity SyndromeCaused by Allopurinol: Analysis of 4 Cases and Literature Review |
| 投稿时间：2016-10-12 修订日期：2016-10-26 |
| DOI： |
| 中文关键词: 别嘌呤醇 药物超敏综合征 不良反应 |
| 英文关键词: |
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| 中文摘要: |
| 目的 分析别嘌呤醇致药物超敏综合症的临床特点及治疗方法。方法 回顾分析我院收治4例别嘌呤醇致药物超敏综合症的临床资料并进行文献复习。 结果 本文4例均因痛风服用别嘌呤醇后出现皮疹伴发热,肝肾功能损害、血液学改变,治疗均予以甲泼尼龙及丙球蛋白治疗,3例治愈,1例死亡。 结论 别嘌呤醇致药物超敏综合症临床以潜伏期长、病情危重、容易反复以及病死率高为特点,早期足量应用糖皮质激素可有效控制。 |
| 英文摘要: |
| Objective To analysis the clinic features and treatment of drug hypersensitivity syndrome(DHS) casused by allopurinol. Methods Clinical data of 4 patients with DHS caused by allopurinol admitted to our hospital in recent years were retrospectively analyzed and literature review. Results Four patients complained of fever, generalized rash, impaired renal and hepatic function and hematologic abnormalities after allopurinol treatment for gout. Three patients had dramatic improvement in clinical, one of the patients died. Conclusion DHS characterized by long incubation period, severe condition, relapse and high mortality rate.Using enough dose of glucocorticoid early or adding large dose of Ig can provide dramatic improvement in clinical condition. |
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