| 高锋.COPD急性加重期患者甲状腺激素水平与患者肺功能和营养状况的相关性[J].浙江中西医结合杂志,2017,27(3): |
| COPD急性加重期患者甲状腺激素水平与患者肺功能和营养状况的相关性 |
| Correlation Analysis of Thyroid Hormone Levels and Pulmonary Function and Nutritional Status of Patients with COPD in Acute Exacerbation |
| 投稿时间：2016-08-30 修订日期：2017-01-04 |
| DOI： |
| 中文关键词: COPD 甲状腺激素 肺功能 营养状况 |
| 英文关键词:COPD thyroid hormone pulmonary function nutritional status |
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| 中文摘要: |
| 目的：探究慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重期患者甲状腺激素水平与患者肺功能和营养状况的相关性。方法：选取于2013年5月～2015年12月期间在我院呼吸内科住院治疗的87例COPD急性加重期患者作为观察组,另选87例同期健康体检者作为对照组,比较两组的血清总三碘甲腺原氨酸(serum total triiodothyornine,TT3)、血清总甲状腺素(serum total thyroid hormone,TT4)、血清游离三碘甲腺原氨酸(serum free triiodothyronine,FT3)、血清游离甲状腺素(serum free thyroid hormone, FT4)、促甲状腺激素(thyroid stimulating hormone,TSH)、肺功能、营养状况,并分析COPD急性加重期患者的甲状腺激素与其肺功能和营养状况的相关性。结果：观察组患者的TSH、FT4、TT4、FT3、TT3、BMI、IBW%、FEV1%预计值以及FEV1/FVC均显著低于对照组,差异具有统计学意义(均P<0.001)。COPD急性加重期患者的FT3、TT3水平与其BMI、IBW%、FEV1%预计值及FEV1/FVC均呈正相关,FT4、TT4水平与其FEV1%预计值及FEV1/FVC呈正相关,差异具有统计学意义(r=0.263、0.281、0.782、0.823、0.271、0.302、0.843、0.881、0.276、0.283、0.251、0.293,均P<0.05),患者的TSH水平与其BMI、IBW%、FEV1%预计值及FEV1/FVC,FT4、TT4水平与其BMI及IBW%均无明显相关性(均P>0.05)。结论：COPD急性加重期患者的甲状腺激素水平常明显降低,且TT3、FT3水平与患者的肺功能和营养状况呈正相关关系,密切监测患者的血清甲状腺激素水平,有助于正确评估患者的病情及治疗效果。 |
| 英文摘要: |
| [Abstract]Objective:To investigate the correlation of thyroid hormone levels and pulmonary function and nutritional status of patients with COPD in acute exacerbation.Methods: 87 patients with COPD in acute exacerbation in our hospital from May 2013 to December 2015 were selected as the observation group, and 87
healthy controls at the same period were selected as the control group.Comparing the thyroid hormone levels,pulmonary function and nutritional status of the objects in both group,and analyzing the correlation of thyroid hormone levels and pulmonary function and nutritional status of the patients in observation group.Results:The level of TSH,FT4,TT4,FT3 and TT3,the BMI,IBW%,FEV1% and FEV1/FVC of the objects in observation group were significantly lower than those of control group(all P<0.001).The level of FT3 and TT3 had positive correlations with BMI,IBW%, FEV1% and FEV1/FVC,and the level of FT4 and TT4 had positive correlations with FEV1% and FEV1/FVC(r=0.263,0.281,0.782,0.823,0.271,0.302,0.843,0.881,0.276, 0.283,0.251,0.293,all P<0.05).The level of TSH had no correlation with BMI,IBW%, FEV1% and FEV1/FVC,and the level of FT4 and TT4 had no correlations with BMI and IBW%(all P>0.05).Conclusion:The thyroid hormone levels of patients with COPD in acute exacerbation decrease significantly.And the level of FT3 and TT3 have positive correlations with patients’pulmonary function and nutritional status. Close monitoring of the thyroid hormone level can help evaluate the pathogenetic condition and prognosis exactly. |
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