| 牟建立.肺结核合并糖尿病患者抗痨药物耐药影响因素的COX模型分析[J].浙江中西医结合杂志,2016,26(12): |
| 肺结核合并糖尿病患者抗痨药物耐药影响因素的COX模型分析 |
| The risk factors to drug-resistant of anti-tuberculosis treatment to diabetic patients with pulmonary tuberculosis by COX proportional hazard model |
| 投稿时间：2016-04-12 修订日期：2016-05-30 |
| DOI： |
| 中文关键词: 【关键词】肺结核病 2型糖尿病 耐药性 危险因素 COX模型分析 |
| 英文关键词:pulmonary tuberculosis, type 2 diabetes mellitus, drug resistant, risk factor, COX proportional hazard model |
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| 中文摘要: |
| 【】目的：应用COX模型分析肺结核合并2型糖尿病(T2DM)患者接受抗痨药物治疗发生耐药性的影响因素。方法：选取164例住院就诊的T2DM合并肺结核患者,依据随访期间患者是否出现抗痨治疗药物耐药性分为：耐药组,65例,出现耐药性；敏感组,99例,未出现耐药性。两组患者均接受正规抗痨药物治疗。收集两组患者的临床资料,通过计算机设立COX比例风险模型,对接受抗痨药物治疗发生耐药性可能产生影响的特征性临床因素进行多因素分析。结果：与敏感组相比,耐药组患者的恶劣生活环境、吸烟、服药不规范、治疗中断、长肺结核病程、空腹血糖(FBS)、餐后2h血糖(PBS)、HbA1c值、BMI值、胰岛素抵抗指数等影响因素存在差异(均P<0.05)。单因素方差分析显示恶劣生活环境、吸烟、服药不规范、治疗中断、长肺结核病程、HbA1c值、胰岛素抵抗与抗痨药物耐药性发生相关(P值均<0.05)；经过COX比例风险模型检测,服药不规范、治疗中断、HbA1c值及胰岛素抵抗是抗痨药物耐药性发生的危险因素(P<0.05)。结论：肺结核合并T2DM患者抗痨药物耐药性发生与服药不规范、治疗中断、HbA1c值及胰岛素抵抗有相关性。 |
| 英文摘要: |
| Objective: To analyze the correlation of drug-resistant of anti-tuberculosis treatment to the risk factors of diabetic patients with pulmonary tuberculosis by COX proportional hazard model. Methods: The 164 diabetic patients diagnosed to pulmonary tuberculosis were chosen and divided into two groups, which were resistant group (65 cases, pulmonary tuberculosis resistance) and sensitive group (99 cases, pulmonary tuberculosis sensitivity), according to the drug-resistant of anti-tuberculosis treatment. Each group’s patients were received the regular anti-tuberculosis treatment. The clinical data was collected and put into computer. A multivariate analysis of these clinical factors to drug-resistant of anti-tuberculosis treatment was been applied to diabetic patients with pulmonary tuberculosis used by computer COX proportional hazard model. Results: Compared to sensitive group, the indexes of poor residence condition, smoking, irregular drug taking, treatment interruptions, long course of pulmonary tuberculosis, fasting blood sugar (FBS), postprandial blood sugar (PBS), HbA1c score, BMI score and insulin resistance index (IRI) in resistant group were different (P<0.05). The correlations between poor residence condition, smoking, irregular drug taking, treatment interruptions, long course of pulmonary tuberculosis, HbA1c score, BMI score and IRI were confirmed to the drug-resistant of anti-tuberculosis treatment (P<0.05) by one-way ANOVA. The factors of irregular drug taking, treatment interruptions, HbA1c and IRI were risk factors to drug-resistant of anti-tuberculosis treatment by COX proportional hazard model (P<0.05). Conclusions: The relationships of drug-resistant of anti-tuberculosis treatment occurrence to diabetic patients with pulmonary tuberculosis were irregular drug taking, treatment interruptions, HbA1c and IRI. |
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