| 叶晓群,金良.首次常规体外受精失败后转行卵泡浆内单精子注射的临床结局分析[J].浙江中西医结合杂志,2016,26(8): |
| 首次常规体外受精失败后转行卵泡浆内单精子注射的临床结局分析 |
| Clinical outcomes of intracytoplasmic sperm injection following fertilization failure in first conventional in vitro fertilization-embryo transfer |
| 投稿时间：2016-03-02 修订日期：2016-03-26 |
| DOI： |
| 中文关键词: 体外受精 卵胞浆内单精子注射 受精障碍 |
| 英文关键词:IVF ICSI fertilization failure |
| 基金项目: |
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| 中文摘要: |
| 【摘要】目的：探讨首次常规体外受精-胚胎移植（in vitro fertilization - embryo transfer，IVF-ET）受精失败后再次助孕治疗转卵泡浆内单精子注射（intracytoplasmic sperm injection， ICSI）的临床效果。方法:自2013年1 月至2014 年12 月对54例因女方因素行常规IVF 受精失败的患者再次助孕治疗转为ICSI（实验组），并与同时期71例因男方因素而用射出精液直接行ICSI（对照组）进行临床结局的比较。结果:实验组受精率、正常受精率、卵裂率、优胚率、植入率、临床妊娠率与对照组比较均无显著性差异（P>0.05）[74.43%(396/532) vs 73.62%(561/762)、62.03%(330/532) vs 65.75%(501/762)、98.79%(326/330) vs 98.80%(495/501)、56.36%(186/330) vs 53.89%(270/501)、 29.47%(28/95) vs 31.07%(32/103)、 50.00%(23/46) vs 47.37%(27/57)]。结论:常规IVF受精失败后再次助孕治疗转ICSI可显著提高受精率，改善临床结局。 |
| 英文摘要: |
| Abstract: Objective to evaluate the clinical outcomes of intracytoplasmic sperm injection (ICSI) in patients with previous fertilization failure in first conventional in vitro fertilization (IVF) cycle. Methods: Between 2013.1 and 2014.12, 54 ICSI cycles following a previous fertilization failure in first conventional IVF (Test group) and 71 direct ICSI cycles using ejaculated spermatozoa (Control group) were performed， and the clinical outcomes of the two groups were analyzed. Results: Fertilization rate， Normal fertilization rate, Cleavage rate, High-quality embryo rate, implantation rate and clinical pregnancy rate in test group showed no significant differences from those in control group [74.43%(396/532) vs 73.62%(561/762), 62.03%(330/532) vs 65.75%(501/762), 98.79%(326/330) vs 98.80%(495/501). 56.36%(186/330) vs 53.89%(270/501). 29.47%(28/95) vs 31.07%(32/103)and 50.00%(23/46) vs 47.37(27/57)%, respectively, P>0.05]. Conclusion: ICSI after a previous fertilization failure of conventional IVF may significantly improve the fertilization rate and clinical outcomes of a second IVF-ET cycle. |
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