| 刘中良,周国儿,田义洲,李飞泽.养肺消积方治疗晚期非小细胞肺癌疗效观察[J].浙江中西医结合杂志,2016,26(6): |
| 养肺消积方治疗晚期非小细胞肺癌疗效观察 |
| Effect of Chinese Medicine Yangfei-Xiaoji decoction on the Survival Status of Patients with advanced NSCLC ,a Cohort Study. |
| 投稿时间：2016-02-23 修订日期：2016-04-22 |
| DOI： |
| 中文关键词: 养肺消积方 非小细胞肺癌 中医疗法 生存分析 队列研究 |
| 英文关键词:Yangfei-Xiaoji decoction advanced NSCLC TCM therapy survival analysis cohort study. |
| 基金项目:舟山市科学技术局项目，编号：2015C31036 |
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| 中文摘要: |
| 目的：探讨养肺消积方对晚期非小细胞肺癌患者的生存分析状况的影响。方法：采用队列研究方法，选取符合入组标准非小细胞肺癌患者107例，其中对照组56例，采用晚期非小细胞肺癌常规一线化疗，观察组组51例，在对照组基础上采用养肺消积方辩证治疗，两组均采用规范化疗、营养支持等西医方法综合治疗。随访观察两组病例一线化疗完成延长时间、生存率（Survival），中位生存期（mOS），Kaplan-Meier生存曲线。结果：与对照组比较，观察组平均化疗时间延长较短，差异有统计学意义（P<0.01）；观察组1年、2年生存率分别为78.43%、29.41%；对照组组分别为53.57%、12.5%，两组整体比较，差异有统计学意义（分别为P<0.01和P<0.05）；总生存期观察组为15±0.27（月）、单纯化疗组13±0.46（月），差异具有统计学意义（P<0.01）。进一步分析显示：一线中药组、全程（一线+维持）中药组中位生存时间分别为15±0.51（月）、15．9±1.03（月）。与对照组比较，MST时间分别提高2个月和2.9个月，差异具有统计学意义（P<0.05和P<0.01）。观察组内部比较，全程中医组高于一线中医组0.9个月，差异有统计学意义（P<0.05）。结论：养肺消积方可以提高晚期非小细胞肺癌患者化疗耐受性、生存率和生存时间。因而，具有较好的临床疗效和科研价值。 |
| 英文摘要: |
| Objective To study the effects of Yangfei-Xiaoji decoction therapy on the survival of patients with advanced NSCLC. Methods Retrospective cohort study was employed. Select 107 cases of advanced NSCLC, of which 51 in treatment group with Yangfei-Xiaoji decoction therapy on the basis of western medicine therapy while 56 in control group with comprehensive treatment of standardized chemotherapy, and other western medicine therapies. The follow-up observation covered survival rate, median survival time and Kaplan-Meier survival curve of the two groups. Results . Yangfei-Xiaoji therapy can improve the survival rate of the observed. The accumulated relative survival rate of Yangfei-Xiaoji decoction group after 1,2 years were 78.43%、29.41% respectively, while 53.57%、12.5% in control group. The comparison between the two groups was statistically significant, with P<0.01 and P<0.05. 15 months in Yangfei-Xiaoji decoction group while 13 months in control group. The comparison between the two groups showed a 2-month prolonging of median survival time and a statistical significance with P<0.01. The median survival time of the First-line chemotherapy and whole process group were respectively 15 and 15.9 months, Compared with the simple chemotherapy group, showed 2-month and 2.9 months respectively prolonging of median survival time and statistical significance with P<0.05 and P<0.01.The internal comparison of the comprehensive treatment group, the whole process is higher than the First-line chemotherapy group. for 0.9 months, the difference was statistically significant (P<0.05). Conclusions Yangfei-Xiaoji decoction therapy can prolong survival time, improve survival rate. Therefore, it is of good clinical efficiency and scientific value. |
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