| 方全中.基质金属蛋白酶-9基因-1562 C/T多态性与 过敏性紫癜并发症的关系[J].浙江中西医结合杂志,2016,26(5): |
| 基质金属蛋白酶-9基因-1562 C/T多态性与 过敏性紫癜并发症的关系 |
| The relationships along matrix metalloproteinase-9 (MMP-9) gene-1562 C/T polymorphism, renal damage and gastrointestinal damage in children with Henoch-Schoenlein purpura. Fang Quanzhong, Guo AiHong, Ding ZhenYao, Yang JiaoJiao. Department of Pediatrics, the People"s Hospital of Cangnan County, Cangnan 325800,china |
| 投稿时间：2015-12-30 修订日期：2016-01-07 |
| DOI： |
| 中文关键词: 基质金属蛋白酶-9 过敏性紫癜 基因多态性 |
| 英文关键词:metalloproteinase-9 gene polymorphism Henoch-Schoenlein purpura |
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| 中文摘要: |
| 目的 研究基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)基因启动子区-1562 C/T多态性与过敏性紫癜(Henoch-Schoenlein purpura,HSP)肾脏及胃肠道损害的关系。方法 收集2014年1月-2015年6月期间确诊HSP的住院患儿资料,共124例,其中男性69例,女性55例,年龄4-12 岁,平均年龄(7.59±2.36)岁。根据有否表现为血尿和(或)蛋白尿,分为肾脏损害组及无肾脏损害组。根据患儿有否并发胃肠道症状(腹痛、便血或大便隐血试验阳性),分为胃肠道损害组及无胃肠道损害组。检测并分析所有HSP患儿的MMP-9-1562 C/T基因型频率及等位基因频率,研究其与肾脏及胃肠道损害的关系。结果 肾脏损害组中CC/CT基因型频率为(CC 62.8%,CT 37.2%),与无肾脏损害组(CC 83.9%,CT16.1%)比较差异有统计学意义(χ2=7.02,P<0.01)。肾脏损害组C/T等位基因频率为C (C 81.4%,T 18.6%),与无肾脏损害组(C 91.9%,T 8.0%)比较差异有统计学意义(χ2= 6.09,P <0.025),并且logistic回归分析示1562T等位基因是HSP患儿发生肾脏损害的危险因素(χ2= 5.67,P<0.025,OR=3.89)。胃肠道损害组与无胃肠道损害组中MMP-9-1562 CC/CT基因型频率及C/T等位基因频率均无显著统计学意义。结论 MMP-9基因-1562C/T多态性与肾脏损害有关,-1562T等位基因加大了HSP患儿发生肾脏损害的风险；-1562T等位基因与HSPD患儿胃肠道损害无明显关系。 |
| 英文摘要: |
| Objective To investigate the relationship along matrix metalloproteinase-9 (MMP-9) gene-1562 C/T polymorphism, renal damage and gastrointestinal damage in children with Henoch-Schoenlein purpura(HSP). Method 124 pediatric cases of HSP (69 boys and 55 girls), the average age was 7.59 years old (3 years-3 years old); These cases were divided according the clinical systoms into renal damage group (43cases) and non-renal damage group (81cases); gastrointestinal damage group (46cases) and non-gastrointestinal damage group (78 cases). Promoter 1562 C/T gene polymorphism of MMP-9 were tested in all these cases. The relationships along MMP-9 gene-1562 C/T polymorphism, renal damage and gastrointestinal damage were analyzed. Results The results of polymorphisms analysis showed that the frequency of CT genotype (37.2%) in renal damage group was significantly higher than 16.1% in non-renal damage group (χ2= 7.02,P <0.01). The frequency of T allele (18.6%) in renal damage group was significantly higher than 8.0% in non- renal damage group (χ2= 6.09,P<0. 025). These cases with HSP carrying the-1562T allele had higher risk of CAL (χ2= 5.67,P<0.025). The frequency of CC/CT genotype or C/T allele showed no significant difference between gastrointestinal damage group and non-gastrointestinal damage group. Conclusions The genetic polymorphism in MMP-9 gene-1562C/T is associated to renal damage in children with HSP; The T allele is a risk factor of renal damage. Due to the frequency of CC/CT showed above there is no significant association between T allele and gastrointestinal damage inHSP. |
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