| 金晨慈,周健慈,颜孙舜,蒋欢欢.慢性阻塞性肺疾病伴焦虑抑郁患者的综合评估治疗[J].浙江中西医结合杂志,2016,26(8): |
| 慢性阻塞性肺疾病伴焦虑抑郁患者的综合评估治疗 |
| Comprehensive evaluation and treatment of chronic obstructive pulmonary disease with anxiety and depression JIN Chenci,ZHOU Jianci,YAN Sunshun,JIANG Huanhuan .Department of Respiratory,Integration of TCM and WM Hospital of Wenzhou,Wenzhou 325000,Zhejiang,China |
| 投稿时间：2015-11-10 修订日期：2016-04-17 |
| DOI： |
| 中文关键词: 慢性阻塞性肺疾病，选择性5-羟色胺再摄取抑制剂，焦虑，抑郁 |
| 英文关键词:Chronic obstructive pulmonary disease Selective serotonin reuptake inhibitors Anxiety Depression |
| 基金项目:温州市医药卫生科学研究项目(NO.2015B03) |
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| 中文摘要: |
| 摘 要 目的 探讨慢性阻塞性肺疾病(C0PD)伴焦虑抑郁患者根据病情严重程度分级予选择性5-羟色胺再摄取抑制剂(SSRIs)治疗,评价SSRIs对不同严重程度患者生活质量的影响。 方法 采用综合医院焦虑抑郁量表测量患者的心理状况,将存在焦虑、抑郁症状的稳定期COPD患者共240例分为治疗组(120例)及对照组(120例),每组再根据COPD病情严重程度的综合评估分为A、B、C、D等四亚组,治疗12周,同时测定治疗前后患者体质指数(BMI)、气流阻塞程度(FEV1、FEV1/FVC)、并用圣乔治呼吸问卷(SGRQ)评价生活质量。 结果 SSRIs治疗12周末,治疗组在C、D级患者的FEV1、FEV1/FVC 、BMI、sGRQ评分与治疗前比较有显著性差异(P<0.05),而对照组治疗前后比较无显著性差异(P＞0.05),治疗组综合医院焦虑抑郁量表评分明显降低(P |
| 英文摘要: |
| Abstract Objective To investigate the treatment of chronic obstructive pulmonary disease (C0PD) with anxiety and depression in patients with selective 5- serotonin re uptake inhibitors (SSRIs) according to the severity of the disease,and to evaluate the effect of SSRIs on the quality of life of patients with different severity. .Methods Using the Hospital Anxiety and Depression Scale measuring the patient"s mental status table, there will be symptoms of anxiety and depression of patients with COPD in stable period a total of 240 patients were divided into two groups: treatment group (120 cases) and control group (120 cases). Each group was further according to the comprehensive assessment of severity of COPD into A、B、C、D and four sub group, 12 weeks of treatment, the simultaneous determination of before and after treatment in patients with body mass index (BMI) and airflow obstruction (FEV1, FEV1 / FVC), and with the St. George"s Respiratory Questionnaire (SGRQ) evaluation of the quality of life. Results SSRIs treatment for 12 weeks, the FEV1, BMI, FEV1/FVC, sGRQ score of the treatment group at C and D level were significantly different (P<0.05), while the control group had no significant difference (P>0.05), and the scores of anxiety and depression in the treatment group were significantly lower (P<0.01). Conclusion Patients with chronic obstructive pulmonary disease with anxiety and depression were significantly improved after SSRIs treatment C、D grade C0PD patients" quality of life, exercise endurance, improve patients" anxiety and depression symptoms, no obvious adverse reactions during the treatment. |
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