| 田义洲,李虹,刘中良,石惠燕,黄立萍,张凌燕.健脾安肠方联合化疗治疗晚期结直肠癌的临床研究[J].浙江中西医结合杂志,2016,26(8): |
| 健脾安肠方联合化疗治疗晚期结直肠癌的临床研究 |
| A Clinical Trail of Jianpianchang decoction combined with chemotherapy on advanced colorectal cancer patients |
| 投稿时间：2015-10-15 修订日期：2016-02-04 |
| DOI： |
| 中文关键词: 健脾安肠方 结直肠癌 晚期 中医药。 |
| 英文关键词:Jianpianchang Decoction Colorectal cancer Advanced Traditional Chinese medicine. |
| 基金项目:舟山市科技局科技计划项目 2011C13049 |
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| 中文摘要: |
| 目的 观察健脾安肠方对晚期结直肠癌化疗的影响。方法 选择本院收治的92例，通过随机对照的方法分为两组各46例，中药干预组采用健脾安肠方联合改良FOLFOX-6方案化疗，单纯化疗组采用改良FOLFOX-6方案化疗。结果 晚期结直肠癌患者基本病机以脾胃虚为主，兼“癌毒”内聚，气滞血瘀、湿热内阻。中药干预组肿瘤控制率、中医症候改善率和生活质量均优于单纯化疗组，差异均有统计学意义；II-IV度神经毒性发生率、白细胞降低率均低于对照组，差异有统计学意义。生存分析显示：与单纯化疗组比较，中药干预组中位PFS时间延长1.5个月，一线化疗周期内进展风险比HR =0.453，95%CI（0.28-0.733），降低进展风险54.7%，P均<0.01差异有统计学意义；中药组中位生存期（MST）提高2个月，随访期内死亡风险比=0.419，95%CI（0.262-0.671），降低死亡风险58.1%，P均<0.05。结论 健脾安肠方可以增强化疗的肿瘤控制率，降低不良反应发生率，提高生活质量；增强化疗敏感性，降低一线化疗进展风险，延长无疾病进展时间；降低随访期内死亡风险，提高中位生存期。 |
| 英文摘要: |
| Abstract: Objective To observe the effect of jianpianchang Decoction in the treatment of advanced colorectal cancer. Methods 92 patients in our hospital, through the method of randomly divided into two groups with 46 cases in each group, traditional Chinese medicine intervention group received jianpianchang decoction combined with modified FOLFOX-6 regimen, chemotherapy group were treated with modified FOLFOX-6 regimen. Results The improvement rate of Chinese medicine symptom, tumor control and quality of life in Chinese medicine intervention group were better than that of simple chemotherapy group, the difference had statistical significance; II-IV grade adverse reactions, such as the neurotoxicity incidence and the decrease of white blood cell were lower than those in the control group, the difference was statistically significant. Survival analysis showed that: compared with the simple chemotherapy group, Chinese medicine intervention group prolonged PFS duration of 1.5 months, the HR of tumor progression was 0.453, 95%CI (0.28-0.733), in the first-line chemotherapy cycle, which was reduced by 54.7%, there was statistical significance, P <0.01; In traditional Chinese medicine group, the median survival time (MST) increased by 2 months. During the follow-up period, the HR of death was 0.419, 95%CI (0.262-0.671), reduced by 58.1%, P <0.05. Conclusion jianpianchang decoction can enhance the control rate of tumor chemotherapy, reduce the incidence of adverse reactions, improve the quality of life and chemotherapy sensitivity, reduce the risk of first-line chemotherapy, prolong the progression free time; reduce the risk of death during the follow-up period, improve the median survival period. |
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