| 谢宏晟,林宇航,蔡丽敏,洪金晶,张丽红.多烯磷脂酰胆碱联合水飞蓟宾(水林佳)胶囊治疗老年非酒精性脂肪性肝病的疗效分析[J].浙江中西医结合杂志,2016,26(1): |
| 多烯磷脂酰胆碱联合水飞蓟宾(水林佳)胶囊治疗老年非酒精性脂肪性肝病的疗效分析 |
| Efficacy of polyene phosphatidylcholine joint silibinin (Capsules and) capsule senile nonalcoholic fatty liver disease |
| 投稿时间：2015-05-27 修订日期：2015-10-22 |
| DOI： |
| 中文关键词: 多烯磷脂酰胆碱 水飞蓟宾(水林佳)胶囊 老年 非酒精性脂肪性肝病 |
| 英文关键词:Polyene phosphatidylcholine Silibinin (Capsules and) capsules Elderly Non-alcoholic fatty liver disease |
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| 中文摘要: |
| 目的 分析多烯磷脂酰胆碱联合水飞蓟宾(水林佳)胶囊治疗老年非酒精性脂肪性肝病的疗效。方法 选取2012年1月-2014年1月期间我院接受治疗的老年非酒精性脂肪性肝病患者150例,采用随机数表法将150例患者分为A、B、C三组,每组各50例患者。A组患者单纯给予多烯磷脂酰胆碱治疗,B组患者单纯给予水飞蓟宾(水林佳)胶囊治疗,C组患者给予多烯磷脂酰胆碱联合水飞蓟宾(水林佳)胶囊治疗。对比治疗后三组患者的肝脏超声积分、血液生化指标、临床疗效。结果 治疗后三组患者的肝脏超声积分较治疗前均显著下降,且C组患者肝脏超声积分显著低于A、B两组患者,比较差异具有统计学意义(p＜0.05)。治疗前三组患者的各项血液生化指标差异不具有统计学意义(p＞0.05)。治疗后三组患者的各项血液生化指标较治疗前显著降低,且C组患者的TC、TG、ALT均显著低于A、B两组患者,比较差异具有统计学意义(p＜0.05)。治疗后C组患者的总有效率显著高于A、B两组患者,比较差异具有统计学意义(p＜0.05)。结论 联合使用多烯磷脂酰胆碱联合水飞蓟宾(水林佳)胶囊治疗老年非酒精性脂肪性肝病的临床疗效显著优于单独使用这两种药物中的一种,可以在临床上进一步推广和使用。 |
| 英文摘要: |
| Objective: To analyze the polyene phosphatidylcholine joint silibinin (Capsules and) Capsule for Treating elderly patients with non-alcoholic fatty liver disease. Methods: January 2012 - January 2014 period in our hospital for treatment of elderly patients with nonalcoholic fatty liver disease 150 cases, using a random number table method 150 patients were divided into A, B, C three groups all 50 patients. A group of patients given pure polyene phosphatidylcholine treatment, group B patients given pure silibinin (Capsules and) capsule therapy, group C were treated with polyene phosphatidylcholine joint silibinin (water Lin Jia) Capsule. Liver ultrasound contrast three groups of patients after treatment points, blood biochemical parameters and clinical efficacy. Results: After treatment, the three groups of patients before liver ultrasound scores than treatment were significantly decreased, and the group C patients with liver ultrasound integration significantly lower than A, B two groups of patients, the difference was statistically significant (p <0.05). Blood biochemical indexes between the three treatment groups were not statistically significant (p> 0.05). After treatment than before treatment significantly reduced the blood biochemical indices of three groups of patients, and group C patients with TC, TG, ALT were significantly lower than A, B patients, a statistically significant difference between the two groups (p <0.05). The total treatment group C patients was significantly higher than A, B patients, a statistically significant difference between the two groups (p <0.05). Conclusion: Combined use of polyene phosphatidylcholine joint silibinin (Capsules and) capsules clinical efficacy in elderly non-alcoholic fatty liver disease was significantly better than the use of these two drugs alone in one, you can clinically further promote and use. |
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