| 金颖,陈明明,金菊花,苏小燕.三种方案根除儿童幽门螺杆菌感染的疗效对比[J].浙江中西医结合杂志,2015,25(12): |
| 三种方案根除儿童幽门螺杆菌感染的疗效对比 |
| Comparison of the eradication of Helicobacter pylori and the drug safety among three methodsJIN Ying,CHEN Mingming,JIN Juhua,SU Xiaoyan (Tongde Hospital of Zhejiang Province,Zhejiang,Hangzhou,310012) |
| 投稿时间：2015-05-09 修订日期：2015-06-08 |
| DOI： |
| 中文关键词: 序贯疗法 三联疗法 阿莫西林/克拉维酸钾 幽门螺杆菌 儿童 |
| 英文关键词:Sequential therapy Triple therapy Amoxicillin and clavulanate potassium Helicobacter pylori Children |
| 基金项目: |
|
| 摘要点击次数: 962 |
| 全文下载次数: 0 |
| 中文摘要: |
| 【摘要】目的：比较三种方法根除儿童幽门螺杆菌（Hp）感染的效果与安全性，指导临床用药。方法：将102例Hp阳性需行根除治疗的患儿随机分为3 组。A组：10d序贯疗法37例，前5d用奥美拉唑、阿莫西林/克拉维酸钾，后5d用奥美拉唑、克拉霉素、替硝唑；B组：33例，阿莫西林/克拉维酸钾、克拉霉素、奥美拉唑，疗程10d；C组：32例，阿莫西林、克拉霉素、奥美拉唑，疗程10d。结果：A、B、C组根除率分别为86.5%、72.7%和62.5%，A组与C组Hp根除率差异有统计学意义（P＜0.05），B组与C组则无差异。3组不良反应率分别18.9%、27.3%和31.3%，差异无统计学意义。结论：序贯疗法根除率高。阿莫西林/克拉维酸钾与阿莫西林对Hp疗效相似。三种方案对儿童均安全。 |
| 英文摘要: |
| 【Abstract】Objective To compare the clinical efficacies of three methods for the treatment of Helicobacter pylori infection，provide a medication guide. Methods A total of 102 children with Hp infection and needed eradication treatment were randomly divided into 3 groups. 10-day sequential therapy group (GROUP A) received omeprazole plus amoxicillin and clavulanate potassium for the first 5 days,then omeprazole, clarithromycin and tinidazole in the next 5 days. GROUP B was given amoxicillin and clavulanate potassium, clarithromycin, omeprazole for total 10 days, while the classical triple therapy group (GROUP C) was given amoxicillin, clarithromycin, omeprazole for 10 days. Results Hp eradication rate was 86.5 % in GROUP A, 72.7% in GROUP B, 62.5% in GROUP C. There was significant difference between GROUP A and GROUP C(P<0.05), while no statistical difference between GROUP B and GROUP C. There was no significant difference among the 3 groups about the incidence rate of adverse reactions, with 18.9 % in GROUP A, 27.3% in GROUP B, 31.3 % in GROUP C. Conclusions 10-day sequential therapy was more effective. Amoxicillin with clavulanate potassium was no more effective than amoxicillin when used in Hp eradication. All 3 methods were safe in children.
【Key words】Sequential therapy；Triple therapy；Amoxicillin and clavulanate potassium；Helicobacter pylori；Children |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
