| 郭君萍,张治芬.肥胖与非肥胖围绝经期综合征患者临床比较研究[J].浙江中西医结合杂志,2015,25(6): |
| 肥胖与非肥胖围绝经期综合征患者临床比较研究 |
| Comparison study on clinical characteristics between obese and non-obese patients with menopausal syndrome |
| 投稿时间：2015-04-02 修订日期：2015-04-21 |
| DOI： |
| 中文关键词: 围绝经期综合征 肥胖/非肥胖 临床分析 |
| 英文关键词:menopausal syndrome obesity/non-obese clinical analysis |
| 基金项目: |
|
| 摘要点击次数: 702 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的 比较肥胖与非肥胖围绝经期综合征（menopausal syndrome，MPS)患者临床症状、代谢水平、生殖内分泌等方面的差异，进一步探讨MPS临床特点和发病机制，为有效分类防治MPS提供询证医学依据。方法 MPS患者361例，健康对照组162例，并根据2000年WHO国际肥胖特别工作组(IOTF)亚太地区肥胖诊断标准将MPS患者分为肥胖组(78人)和非肥胖组(283人)。通过改良kupperman评分表对其症状进行评估，记录身高、体重，测定FSH、LH、E2、P、PRL、空腹血糖、血脂、甲状腺功能指标及肾功能指标等，并加以对照研究。 结果 本研究发现与对照相比，MPS患者体重（t=-2.107，P=0.036）, 肌酐（t=-3.907，P<0.001），甘油三酯（Z =-2.184，P=0.029），总胆固醇（Z =-2.508，P=0.012），LDL（Z =-2.668，P=0.008），FT4（t=-2.589，P=0.01），GPT（t=2.853，P=0.005），GOT（t=5.262，P<0.001），尿素（t=2.325，P=0.021）和血糖（Z =-1.992，P=0.046）均比对照女性高。MPS患者中，改良kupperman评分肥胖组总分（21.1±10.1分）显著高于非肥胖组总分（18.4±9.7分），组间差异具有统计学意义（t=-2.186，P=0.029）。其中肥胖组出现情绪波动的频率显著高于非肥胖组（X2=8.996，P=0.029）; 且肥胖组出现潮热多汗（t=-2.264，P=0.024）情绪波动（t=-2.974，P=0.003）和骨关节痛的程度更严重（t=-2.676，P=0.008）。与非肥胖组相比，肥胖组收缩压（t=-2.018，P=0.044），舒张压（t=-2.871，P=0.004），GPT（t=-3.027，P=0.003）,甘油三酯（t=-2.256，P=0.025），血糖（t=-4.797，P<0.001），胰岛素（t=-2.485，P=0.014），FT4（t=2.331，P=0.021），Wbc（t=-2.712，P=0.008）均呈现显著增高；非肥胖组的FSH显著高于肥胖组（t=8.315，P=0.021）。结论 肥胖MPS比非肥胖者MPS临床症状更严重，更容易出现情绪波动，更容易出现血脂、血糖等代谢异常，容易出现血压异常，临床中更要重视监测血压、血脂、血糖以及激素水平，重视心理干预、激素补充和生活方式干预。 |
| 英文摘要: |
| Objective To compare clinical, endocrine and metabolic characteristics between obese and non-obese patients with menopausal syndrome, to explore the clinical characteristics and pathogenesis of menopausal syndrome as the classified guidance for its prevention. Methods there are 361 patients with menopausal syndrome, 162 healthy controls; menopausal syndrome patients divided 78 into obesity group and 283 into non-obese group. Evaluated its symptoms through improved kupperman, recorded height, weight, and the levels of FSH, LH, E2, P, PRL, fasting blood glucose, blood lipid, thyroid function, renal function and other indicators, and control study. Results Compared with the control group women, menopausal syndrome patients weight (t= 2.107, P=2.107), creatinine (t= 3.907, P<0.001), triglyceride (Z=2.184, P=2.184), total cholesterol (Z =2.508, P=2.508), LDL (Z = 2.668, P=2.668), FT4 (t=2.589, P= 2.589), GPT (t=2.853, P=2.853), and GOT (t=5.262, P<0.001), urea (t=2.325, P= 2.325) and blood glucose (Z=1.992, P=1.992) were higher than the menopausal women; But the systolic blood pressure (t=2.875, P=0.004) was significantly lower. Patients with menopausal syndrome, total score of obesity group is significantly higher than non-obese group (t=2.186, P= 2.186). The obesity group had a significantly higher frequency of the occurrence of emotional fluctuation than non-obese group(X2=8.996，P=0.029); and more serious of hot flashes sweat (t=-2.264，P=0.024）,emotional fluctuation(t=-2.974，P=0.003)and joint pain（t=-2.676，P=0.008）. Compared to non-obese group, obese systolic blood pressure (t=2.018, P=2.018), diastolic blood pressure (t=2.871, P= 2.871), GPT (t= 3.027, P=3.027), triglycerides (t=2.256, P= 2.256), blood glucose (t=4.797, P<0.001), insulin (t=2.485, P=2.485), FT4 (t=2.331, P=2.331), the wbc (t= 2.712, P=2.712) are present significantly higher；While FSH is lower (t=8.315, P=8.315). Conclusion In order to protect the menopausal women's physical and mental health, it needs us to focus on their emotional fluctuation, monitoring the blood pressure, blood lipid, blood glucose, and hormone levels, to effective prevention and treatment of women menopause syndrome.
【key words】 menopausal syndrome obesity/non-obese clinical analysis |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
