| 肖凤春,张春丽,方蓉,毛玉萍,倪桂宝.P-STAT3和FHIT在卵巢上皮性肿瘤的表达及相关性研究[J].浙江中西医结合杂志,2015,25(8): |
| P-STAT3和FHIT在卵巢上皮性肿瘤的表达及相关性研究 |
| Expression of p-STAT3 and FHIT in epithelial ovarian tumors and its relationshipsXIAO Fengchun , ZHANG Chunli, FANG Rong , Zhejiang Provincial Hospital of TCM,HangZhou(310006),China |
| 投稿时间：2015-03-31 修订日期：2015-05-11 |
| DOI： |
| 中文关键词: 信号转导和转录激活因子 脆性组氨酸三联体基因 卵巢肿瘤 免疫组化 |
| 英文关键词:P-STAT3, FHIT, Ovarian Tumors,Immunohistochemistry |
| 基金项目:浙江省中医药大学校级课题项目 (No.201111) |
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| 中文摘要: |
| 目的 研究p-STAT3和FHIT在卵巢上皮性肿瘤组织中的表达及其与卵巢上皮肿瘤临床病理参数的关系。方法 选取卵巢癌组40例、卵巢交界性肿瘤组20例、卵巢良性腺瘤组20例,采用S-P免疫组织化学方法检测肿瘤组织中p-STAT3和FHIT的表达,并对免疫组化染色结果进行半定量分析。结果 p-STAT3在卵巢癌组的表达高于良性组及交界性肿瘤组的表达,FHIT在卵巢癌组的表达低于良性组及交界性肿瘤组的表达,差异有统计学意义(P<0.05)；p-STAT3和 FHIT在卵巢癌淋巴结转移病例中的表达有显著性差异(P<0.05)；卵巢癌组织中p-STAT3和FHIT的表达呈显著负相关(P<0.05)。结论 p-STAT3和FHIT在卵巢肿瘤的发生、发展中起着重要作用,两项指标的联合检测有助于判断卵巢癌的淋巴结转移及早期预后。 |
| 英文摘要: |
| Objective To detect the expression of p-STAT3 and FHIT in epithelial ovarian tumors, and to investigate the relationships between the expression and clinic pathological parameters of epithelial ovarian tumors. Methods We conducted a study in 40 cases of ovarian cancers, 20 cases of borderline ovarian tumors and 20 cases of benign ovarian adenomas. Immunohistochemistry using streptavidin-peroxidase (SP) method was adopted to detect the expression of p-STAT3 and FHIT in each tissue. The results of immunohistochemical staining were studied by half quantitative analysis. Results The positive expression rate of p-STAT3 was higher in ovarian cancer group than the borderline ovarian tumor group and the benign ovarian adenoma group, there were significant difference (P<0.05). There were also significant differences among the three groups in terms of the negative expression rate of FHIT (P<0.05). The expression of p-STAT3 and FHIT was significantly different in lymph node metastasis of ovarian cancer (P<0.05). The expression of p-STAT3 had a significantnegative correlation with the expression of FHIT in ovarian cancer (P<0.05). Conclusion The abnormal expression of p-STAT3 and FHIT may play an important role in the initiation and development of ovarian tumors. The combined detection of p-STAT3 and FHIT is helpful for evaluating the lymph node metastasis and early prognosis of ovarian tumors. |
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