| 董权,刘江.63例小肠间质瘤病例临床与病理特点分析[J].浙江中西医结合杂志,2015,25(6): |
| 63例小肠间质瘤病例临床与病理特点分析 |
| 63 cases of small intestinal stromal tumor cases clinical and pathological characteristics analysis |
| 投稿时间：2014-10-31 修订日期：2015-03-31 |
| DOI： |
| 中文关键词: 胃肠间质瘤 小肠间质瘤 临床表现 免疫组织化学 |
| 英文关键词:Gastrointestinal stromal tumor Small intestinal stromal tumor Clinical manifestations Immunohistochemistry |
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| 中文摘要: |
| 目的：探讨小肠间质瘤的临床特点及病理特征，提高对小肠间质瘤的诊治及认识 方法：回顾分析63例手术确诊的小肠间质瘤病例；总结病史特点及肿瘤细胞形态、免疫组织化学特点，分析各免疫标记物与肿瘤危险度之间关系 结果：63例病例发病中位年龄57岁，男性发病率略高于女性，主要表现为消化道出血和（或）腹痛（占80.9%）。其中出血病例发病首诊时血红蛋白最小26g/L平均69.4g/L 中位值66.5g/L。细胞大多呈梭形。CD117阳性率98.4%。CD117、CD34、Desmin、SMA、S-100、Ki-67与肿瘤危险度无明显相关性（P=0.907，0.805，0.778，0.270，0.839，0.184）结论：小肠间质瘤好发于中老年，男性发病率略高于女性，主要表现为消化道出血和（或）腹痛。出血病例贫血严重。病理大多呈CD117阳性梭形细胞。CD117、CD34、Desmin、SMA、S-100、Ki-67与肿瘤危险度无明显相关性。根据NIH胃肠间质瘤危险度分级主要分成低危和高危组；其余极低危组和中危组病例极少，按此分级系统对术后指导用药可以较明确区分。 |
| 英文摘要: |
| Objective: To study the clinical characteristics and pathological characteristics of small intestinal stromal tumors(SIST), improve the understanding of the diagnosis and treatment of SIST. Methods: retrospectively analyse 63 cases surgical diagnosis of SIST; Summarize the history, tumor cell morphology and immunohistochemical characteristics, analyse the relationship between immune markers and tumor risk. Results: the incidence of 63 cases aged 57, male incidence is slightly higher than female, mainly for gastrointestinal bleeding and/or abdominal pain (80.9%). With hemorrhage cases for the first time to see a doctor, the minimum value of hemoglobin 26 g/L, on average 69.4 g/L, the median value 66.5 g/L. Most cells were in the spindle. CD117 positive rate was 98.4%. CD117, CD34, Desmin, SMA, S - 100, and Ki - 67 had no obvious correlation with cancer risk (P = 0.907, 0.805, 0.907, 0.805, 0.839, 0.184). Conclusion: SIST occurs in middle and old-aged, male incidence is slightly higher than that of women, mainly for gastrointestinal bleeding and/or abdominal pain. Cases of bleeding had severe anemia performance. Most of histological CD117 were positive spindle cells. CD117, CD34, Desmin, SMA, S - 100, and Ki - 67 had no obvious correlation with cancer risk.According to the NIH Gastrointestinal stromal tumor risk classification is mainly divided into low risk and high risk groups; The rest of the extremely low risk group and moderate group is very little, According to the classification system, postoperative medication can be clearly identified. |
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