| 李博,毛颖民,杨建生,赵仲生.MMP-11 在胃癌组织中的表达及其与浸润转移的关系[J].浙江中西医结合杂志,2015,25(5): |
| MMP-11 在胃癌组织中的表达及其与浸润转移的关系 |
| The expression of MMP-11 in Gastric Carcinoma and Its Relationship with Cancer Invasion and Metastasis |
| 投稿时间：2014-10-15 修订日期：2015-01-16 |
| DOI： |
| 中文关键词: 胃肿瘤 肿瘤浸润，肿瘤转移 基质金属蛋白酶-11 |
| 英文关键词:gastric neoplasma neoplasma invasion neoplasma metastasis matrix metalloproteinases -11 |
| 基金项目:国家卫生公益性行业专项经费(200802112);浙江省医药卫生科技计划一般研究项目（201475879） |
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| 中文摘要: |
| 【摘要】目的 探讨MMP-11蛋白的表达及其与肿瘤浸润转移的关系。方法 免疫组织化学技术分析436例胃癌组织及92例邻近正常胃粘膜组织石蜡标本中MMP-11的表达。结果 MMP-11在正常胃粘膜组织中的表达低于胃癌组织 （0 vs 47.5% χ2=73.424，P<0.01）。MMP-11表达与胃癌患者肿瘤大小、分化、侵犯深度、分期、淋巴转移，远处转移，脉管侵犯、Lauren分型相关，而与组织类型、性别无关。胃癌患者中肿瘤大小≥5cm患者的MMP-11阳性表达率为62.8%，明显高于肿瘤大小<5cm患者（36.7%。χ2=28.781， P<0.001）；弥漫型胃癌患者的MMP-11阳性表达率为明显高于肠型患者（85.9% VS 10.7%。χ2=246.751， P<0.001）；T3、T4期胃癌患者的MMP-11阳性表达率分别为58.6%、96.2%，明显高于T1、T2期的10.5%、30.3%，（χ2=80.969， P<0.001）；Ⅲ期、Ⅳ期胃癌患者的MMP-11阳性表达率分别为68.8%、95.7%，明显高于Ⅰ期、Ⅱ期MMP-11的7.8%、14.4%（χ2=198.170， P<0.001）；脉管侵犯患者的MMP-11阳性表达率明显高于无脉管侵犯者（70.0% VS 16.4%。χ2=122.193， P<0.001）；淋巴结转移胃癌患者的MMP-11阳性表达率为68.9%，明显高于无淋巴结转移MMP-11的阳性表达率（12.7%。χ2=130.382， P<0.001）；远处转移胃癌患者的MMP-11阳性表达率为95.1%，明显高于无远处转移者（39.7%。χ2=64.455， P<0.001）。根据多因素logistic回归分析，MMP11的表达在TNM分期高，脉管侵犯，远处转移的患者中发生率高，结论 MMP-11与胃癌的发生发展有关，参与了胃癌的浸润转移进程。检测MMP-11的表达可作为判断胃癌生物学行为的重要参考指标。
【关键词】胃肿瘤；肿瘤浸润，肿瘤转移；基质金属蛋白酶-11 |
| 英文摘要: |
| 【 Abstract】 Purpose： To investigete the expression of MMP-11 and its relationship with invasion and metastasis in gastric cancer。Methods: MMP-11 expression in sample tissues of 436 cases with gastric cancer and 92 cases of cancer adjacent gastric mucosa was detected immunohisochemically. Results: MMP-11 expression in cancer adjacent gastric mucosa was significantly lower than that in gastric cancer （0 vs 47.5% χ2=73.424，P<0.01）. MMP-11 expression was related to tumor size, differentiation, depth of invasion, stage, lymph node metastasis, distant metastasis, vascular invasion, Lauren classification of gastric cancer ,except the histologic type and gender . MMP-11 positive expression rate in gastric cancer patients with tumor size≥ 5cm ( 62.8%), increased significantly than that in patients with tumor size <5cm（36.7%。χ2=28.781， P<0.001）； MMP-11 positive expression rate in patients with diffusing type cancer ( 85.0%), increased significantly than that in intestinal-type cancer（10.7%。χ2=246.751， P<0.001）；MMP-11 positive expression rate in patients stage T3 and T4 (58.6%、96.2%), increased significantly than that in T1, T2 stage patient （10.5%、30.3%，χ2=80.969， P<0.001）；MMP-11 positive expression rate in patients with stage Ⅲ, IV (68.8%, 95.7%), increased significantly than that in stage Ⅰ, II patients（7.8%, 14.4%.χ2 = 198.170, P <0.001).MMP-11 positive expression rate in patients with vascular invasion (70.0%), increased significantly than that in patients without vascular invasion MMP-11（16.4%。χ2= 122.193， P<0.001）；MMP-11 positive expression rate in patients with lymph node metastasis (68.9%), increased significantly than that in patients without lymph node metastasis（12.7%。χ2=130.382， P<0.001）；MMP-11 positive expression rate in patients with distant metastasis (95.1%), increased significantly than that in patients without distant metastasis（39.7%。χ2=64.455， P<0.001）；According to the multi-factor logistic regression analysis, MMP11 high expression special in high TNM staging, vascular invasion, distant metastasis patients,Conclusion: MMP-11 relates to the carcinogenesis of ganstric cancer ,and involves in process of invasion and metastasis of gastric cancer .MMP-11expression could be used as an important reference indicator for biological behavior for gastric cancer.
【Subject words】: gastric neoplasma ;neoplasma invasion ;neoplasma metastasis; matrix metalloproteinases -11 |
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