| 杨俊,徐旭东.应用COX比例风险模型对周围型非小细胞肺癌术后切缘癌影响因素的分析[J].浙江中西医结合杂志,2014,24(12): |
| 应用COX比例风险模型对周围型非小细胞肺癌术后切缘癌影响因素的分析 |
| The analyses of risk factors on residual tumor of the bronchial margin in patients with peripheral non small cell lung cancer by COX proportional hazard model |
| 投稿时间：2014-10-09 修订日期：2014-10-22 |
| DOI： |
| 中文关键词: 周围型非小细胞肺癌 |
| 英文关键词:peripheral non small cell lung cancer, acute exacerbation, residual tumor of the bronchial margin, risk facter, COX proportional hazard model |
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| 中文摘要: |
| 【】目的：探讨周围型非小细胞肺癌患者接受肺癌切除术后切缘癌残留的危险因素及其相关性。方法：对68例接受肺癌切除术的周围型非小细胞肺癌患者进行研究。按术后切缘癌残留分为：残留组,38例,术后证实切缘癌残留；对照组,30例,术后证实无切缘癌残留。比较两组患者的性别、年龄、吸烟史、手术术式、病理组织类型、病理分期、分化程度、术后治疗等因素的差异。通过计算机COX比例风险模型,对术后切缘癌残留可能产生影响的8个特征性因素进行多因素分析。结果：全组1年随访率为92.65%(63/68),全组1年生存率为89.71%(61/68)。与对照组相比,残留组的病理组织类型、病理分期、分化程度存在差异(P<0.05),而残留组的性别、年龄、吸烟史、手术术式、术后治疗无差异(P>0.05)。多因素分析显示病理组织类型及分化程度是术后切缘癌残留发生的危险因素(P<0.05)。结论：腺癌及低分化程度因素的周围型非小细胞肺癌患者术后切缘癌残留的可能性较高。 |
| 英文摘要: |
| Objective To analyze the risk factors on residual tumor of the bronchial margin in patients with peripheral non small cell lung cancer (PNSCLC). Methods A total of 68 patients with PNSCLC received resection of lung cancer were collected to study. All patients were divided into two groups, residual group (38 cases, confirmed to residual tumor of the bronchial margin) and control group (30 cases, non-confirmed to residual tumor of the bronchial margin). The indexes of gender, age, history of smoking, operative methods, pathological types, pathological stage, degree of differentiation and postoperative treatment were compared between two groups. The 8 possible risk factors which could affect residual tumor of the bronchial margin in patients with PNSCLC were selected. A multivariate analysis of these individual variables was been applied to patients with PNSCLC used by computer COX proportional hazard model. Results The follow-up rate was 92.65%(63/68) over 1 year. The over-all survival rate was 89.71%(61/68) at 1 year. Compared to control group, the indexes of pathological types, pathological stage, degree of differentiation in residual group were different (P<0.05), but the indexes of gender, age, history of smoking, operative methods and postoperative treatment in residual group were no different (P>0.05). The indexes of pathological types and degree of differentiation were the risk factors influencing residual tumor of the bronchial margin of patients with PNSCLC by multivariate analysis (P<0.05). Conclusion The possibility of patients with PNSCLC combined with adenocarcinoma and low-degree of differentiation should been given close attention to the possibility of PNSCLC. |
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