| 王海.肝硬化患者网织血小板与血小板参数之间的相关性及临床意义[J].浙江中西医结合杂志,2015,25(3): |
| 肝硬化患者网织血小板与血小板参数之间的相关性及临床意义 |
| The clinical significance of correlationS between Reticulated Platelets and Platelets Parameters in patients with liver cirrhosis |
| 投稿时间：2014-07-10 修订日期：2014-12-12 |
| DOI： |
| 中文关键词: 肝硬化 网织血小板 血小板 大血小板比率 |
| 英文关键词:Liver cirrhosis Reticulated platelets PLT P-LCR |
| 基金项目:浙江省科技厅公益技术应用研究项目(课题号：2013C37066)作者单位( 1.浙江省立同德医院检验科2. 杭州市儿童医院检验科,杭州310003)电子邮箱：wanghai.5188@163.com |
|
| 摘要点击次数: 981 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的:观察肝硬化患者和慢性肝炎患者外周血中网织血小板(RP)、PLT、MPV、PDW、P-LCR的变化，探讨肝硬化患者和慢性肝炎患者PLT减少的原因。方法:肝硬化患者30名、慢性肝炎患者42名及健康体检者20名；检测外周血中PLT、MPV、PDW、P-LCR，流式细胞术检测RP％。结果：与对照组比较: 肝硬化组PLT、RP%、RP绝对数降低、P-LCR增加具有显著性（P <0.05）；慢性肝炎组PLT降低、MPV、PDW、P-LCR增加具有显著性（P <0.05）。肝硬化组与慢性肝炎组相比较:PLT、RP%、RP绝对数降低具有显著性（P<0.05）。RP%与MPV、PDW、P-LCR间均具有良好相关性（P <0.01）。结论: 肝硬化患者PLT降低与RP减少、PLT破坏过多有关，而慢性肝炎患者PLT降低与PLT破坏过多有关。 |
| 英文摘要: |
| Objective To determine the reason of thrombocytopenia in patients with liver cirrhosis, observed the change of PLT MPV、PDW、P-LCR 、RP%、RP in patients with liver cirrhosis and Patients with chronic hepatitis.
Methods Peripheral blood PLT, MPV, PDW, P-LCR in 30 patients with liver cirrhosis 、42 Patients with chronic hepatitis and 20 healthy volunteers were detected by Blood cell count in; The levels of RP% were analysed by flow cytometer(FCM).And analyze the relationship between the reticulated platelets and the platelets parameters .
Results Compared with healthy control, the numbers of peripheral PLT、RP%、absolute counts of RP in patients with liver cirrhosis were significantly decreased(P <0.05), P-LCR were higher than healthy control (P <0.05).While the numbers of MPV、PDW、P-LCR in patients with chronic hepatitis were higher than those in the healthy control group(P <0.05), PLT were significantly decreased(P <0.05). Compared patients with liver cirrhosis and patients with chronic hepatitis, the numbers of peripheral PLT、RP%、absolute counts of RP in patients with liver cirrhosis were significantly decreased(P <0.05). There are no correlation between RP% and PLT,but RP% and MPV、PDW、P-LCR have good correlation(P <0.05).
Conclusions The decreased production of reticulated platelets and excessive destruction of the platelet might play an important role for thrombocytopenia in patients with liver cirrhosis; And thrombocytopenia in patients with chronic hepatitis were because of excessive destruction of the platelet. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
