| 吴柳青,李宇,林峥.地佐辛复合丙泊酚用于胃肠镜检查的临床效果观察[J].浙江中西医结合杂志,2014,24(12): |
| 地佐辛复合丙泊酚用于胃肠镜检查的临床效果观察 |
| Observation of dezocine combined with propofol in clinical gastrointestinal endoscopy |
| 投稿时间：2014-06-07 修订日期：2014-10-10 |
| DOI： |
| 中文关键词: 地佐辛 丙泊酚 无痛胃肠镜 麻醉 疼痛 呼吸 |
| 英文关键词:Dezocine Propofol Painless gastroscopy Anesthesia Pain Respiration |
| 基金项目: |
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| 中文摘要: |
| 目的：研究地佐辛复合丙泊酚用于胃肠镜检查的临床效果。方法：选择无痛胃肠镜检查的患者280例平均分为对照组(n=140,使用芬太尼联合丙泊酚麻醉)和研究组(n=140,使用地佐辛联合丙泊酚麻醉),观察两组患者的身体参数的变化、疼痛感觉、丙泊酚的用量、唤醒时间以及不良反应情况。结果：两组患者进行无痛胃肠镜检查,在麻醉后将电子胃镜置入时均会引起心率、MAP、呼吸频率和血氧饱和度的降低,在取出电子胃镜及苏醒时均会渐渐升高直至复原。但是研究组患者的呼吸频率在电子胃镜置入及取出时的变化值(-3.8和-1.1)均显著低于对照组(-4.9和-2.3,P＜0.05),在电子胃镜置入时血氧饱和度变化值(-2.5)显著低于对照组(-3.9,P＜0.05)。两组患者在检查中的疼痛级别主要集中在0级,少量在I-II级,两组患者苏醒后的VAS评分均为0,表示均无疼痛的感觉,组间比较均无显著性意义。研究组的丙泊酚用量为121.5 mg,显著低于对照组的130.2mg(P＜0.05),研究组唤醒时间显著低于对照组(4.7和5.6 min, P＜0.05),研究组患者发生呼吸抑制和恶心呕吐等不良反应的概率均显著低于对照组(P＜0.05)。结论：使用地佐辛复合丙泊酚用于胃肠镜检查的麻醉可以改善患者的呼吸状况和血氧饱和度,减少丙泊酚的用量,降低呼吸抑制和恶心呕吐的作用。 |
| 英文摘要: |
| Objective: To study the clinical effect of dezocine combined with propofol for gastroscopy and colonoscopy. Methods: 280 patientspainless gastrointestinal endoscopywere chosen divided into control group (n=140, the use of fentanyl combined with propofol anesthesia) or study group (n=140, using dezocine combined with propofol anesthesia) randomly, physical parameters changes, pain, propofol dosage, awake time and adverse reaction conditions in two groups of patientswere observed. Results:The heart rate, MAP, respiratory rate and oxygen saturation in two groups of patientswere reduced in anesthesia period of painless gastrointestinal endoscopyplacemrnt and elevated gradually until electronic gastroscope removement and restoration. But the respiratory rate of study group patients in study group and change out values (-3.8 and -1.1) were significantly lower than those in the control group (-4.9 and -2.3, P < 0.05), changes of blood oxygen saturation in study group at electronic gastroscope movement period (-2.5) was significantly lower than that of the control group (-3.9, P < 0.05). The pain level in the inspection were mainly concentrated in the 0 stage, a few at the I-II level, two patients VAS score in recovery period were all 0, said there were no pain feeling, comparisons between groups were non significant. Propofol dosage in study groupwas 121.5mg, significantly lower than the control group 130.2mg (P < 0.05), the study group wake-up time was significantly lower than the control group (4.7 and 5.6 min), the probability of the study group patients adverse respiratory depression and nausea and vomiting were significantly lower than those in the control group (P < 0.05). Conclusion: Dezocine combined with propofol for anesthesia can improve respiratory and blood oxygen saturation reduction, reduce propofol dosage, reduce respiratory inhibition and nausea and vomiting effect in patients with painlessgastrointestinal endoscopy. |
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