| 姜跃炜,叶瑾,朱小区.二草清肝汤联合干扰素治疗慢性乙型肝炎疗效观察[J].浙江中西医结合杂志,2014,24(11): |
| 二草清肝汤联合干扰素治疗慢性乙型肝炎疗效观察 |
| Combination of Ercao Qinggan Decoction on the interferon therapy in patients with chronic hepatitis B |
| 投稿时间：2014-05-13 修订日期：2014-08-17 |
| DOI： |
| 中文关键词: 二草清肝汤 干扰素 慢性乙型肝炎 |
| 英文关键词:ErcaoQinggan decoction interferon chronic hepatitis B |
| 基金项目:温州市中医药卫生科研项目基金(No. 2012ZB006) |
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| 中文摘要: |
| 目的: 研究二草清肝汤联合干扰素对治疗慢性乙型肝炎患者疗效的影响。方法: 将慢性乙型肝炎患者随机分为治疗组和对照组，对照组给予干扰素治疗，治疗组在对照组基础上加服二草清肝汤治疗，疗程48周。分别于治疗前、治疗后24周和48周观察两组血中丙氨酸氨基转移酶(ALT)、乙肝表面抗原定量(HBsAg)，e抗原定量(HBeAg)，乙肝病毒载量(HBV-DNA)，白细胞(WBC),血小板(PLT),甲胎蛋白(AFP),透明质酸(HA)等指标的变化。结果: 两组在治疗48周后，治疗组的有效应答率比对照组显著提高（P<0.05）。治疗组和对照组的ALT、HBeAg、 HBV-DNA、 AFP和HA等指标在治疗后比治疗前均有显著性下降（P均<0.05）。但在治疗24周时治疗组比对照组下降更为显著（P均<0.05）。治疗组和对照组患者治疗后都引起HBsAg、 WBC和PLT的显著性下降，两组比较无显著性差异（P>0.05）。结论: 二草清肝汤联合干扰素治疗慢乙肝患者在抗病毒，保肝护肝，抗纤维化这几方面有增强干扰素疗效的作用，但在干扰素引起WBC和PLT减少的副作用方面没有效果。 |
| 英文摘要: |
| 【Abstract】 Objective: To study the effect of the Ercao Qinggan Decoction on interferon therapy in patients with chronic hepatitis B. Methods: Chronic hepatitis B patients were randomly divided into treatment group and control group. The control group received interferon therapy, the treatment group were based on the Ercao Qinggan Decoction therapy, 48 weeks of treatment. Two groups before treatment and after treatment 24 weeks and 48 weeks ALT, HBsAg quantitative, HBeAg quantitative, HBV- DNA, WBC, PLT, AFP, HA, were respectively measured to observe the change of the two groups of these indicators. Results: After 48 weeks of treatment, the effective response rate in the treatment group was significantly higher than the control group (P <0.05) . Treatment group and control group，ALT, HBeAg， HBV-DNA, AFP and HA after treatment were significantly decreased than before treatment(P <0.05) .However, the treatment group, in the treatment of 24 weeks decreased more significantly than the control group (P <0.05). Treatment group and control group patients after treatment HBsAg,WBC and PLT levels significantly decreased ,but there was no significant difference between the two groups(P>0.05). Conclusion: Ercao Qinggan Decoction combined with interferon treatment of chronic hepatitis B patients have a role in enhancing the efficacy of interferon antiviral, hepatoprotective, anti-fibrosis in these areas, but in interferon induced WBC and PLT decreased side effects have no effect. |
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