| 黄桔秀,朱慧民,金礼通,章娅妮.两种液体复苏方案在感染性休克治疗中的比较[J].浙江中西医结合杂志,2014,24(8): |
| 两种液体复苏方案在感染性休克治疗中的比较 |
| Study of two different modes of fluid resuscitation in patients with septic Shock |
| 投稿时间：2014-02-19 修订日期：2014-05-05 |
| DOI： |
| 中文关键词: 去甲肾上腺素 感染性休克 APACHEⅡ评分 早期液体复苏 |
| 英文关键词:Norepinephrine Septic Shock APACHEⅡ score Early fluid resuscitation |
| 基金项目: |
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| 中文摘要: |
| 【】 目的 观察早期应用去甲肾上腺素的液体复苏方案在治疗感染性休克患者的临床疗效并探讨其机制。方法 选择重症监护病房(ICU)住院治疗的感染性休克患者60例,随机分为早期应用去甲肾上腺素的液体复苏方案治疗组(A组,30例)与传统补液方案治疗组(B组,30例),A组采用早期应用去甲肾上腺素的液体复苏方案,即在基础治疗的同时,经中心静脉泵入去甲肾上腺素。B组采用传统的补液方法即在充分扩充血容量的基础上若不能维持有效的灌注压则再加用去甲肾上腺素。结果 A组6h复苏成功率高于B组,住ICU时间短于B组。A组患者的血乳酸、肾功能及APACHEII评分的改善明显快于B组,两组比较差异具有统计学意义(P<0.05)。两组患者28天内死亡率没有明显差异(P＞0.05)。结论 早期应用去甲肾上腺素的液体复苏方案能明显改善感染性休克患者的组织灌注, 提高6h复苏成功率,缩短住ICU时间。早期应用去甲肾上腺素的液体复苏方案是治疗感染性休克的有效手段。 |
| 英文摘要: |
| 【】 Objective :By observing the efficieny of different modes of fluid resuscitation in patients with septic Shock,we aimed to explore its mechanismand. Methods: Sixty patients with septic shock were selected from intensive care unit(ICU) of our hospital and randomly divided into two group:fluid resuscitation with early use of norepinephrine group,( goup A,30 patients) and conventional fluid resuscitation group(group B ,30 patients). In the goup A, norepinephrine was used at the beginning of fluid resuscitation;In group B, norepinephrine was used on the basis of fully expand blood capacity if unable to maintain effective perfusion pressure plus.Results: The recovery success rate in six hour of group A is higher than that of proup B, the length of stay in ICU of group A is shorter than that of group B(P<0.05).After treatment,Cuctic acid、Creatinine of blood、acute physiology and chronic health evaluation II (APACHEII) score of group A were improved more than that of the group B.There was a significant difference (P<0.05).There was no significant difference in 28-day mortality rate between the two group.Conclusion: The study demonstrated that fluid resuscitation with early use of norepinephrine is an effective treatment method for septic Shock. |
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