| 孙红.防喘膏对哮喘大鼠的疗效及IL-12、13水平的影响孙红 杭州市红十字会医院儿科 杭州 310003[J].浙江中西医结合杂志,2014,24(9): |
| 防喘膏对哮喘大鼠的疗效及IL-12、13水平的影响孙红 杭州市红十字会医院儿科 杭州 310003 |
| Effect of Fangchuangao(防喘膏) Application on Bronchial Asthma Rats and the Content of IL-12、13 in Rats |
| 投稿时间：2014-01-25 修订日期：2014-04-03 |
| DOI： |
| 中文关键词: 哮喘 穴位敷贴法 白细胞介素-12 白细胞介素-13 防喘膏 |
| 英文关键词:Asthma Acupoint Application IL-12 IL-13 Fangchuangao |
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| 中文摘要: |
| 目的 观察防喘膏对哮喘大鼠的疗效及对白细胞介素（IL）-12、13水平的影响。方法 将麻黄、大黄、白芥子、地龙、细辛、甘遂六味药按比例研成末，以生姜汁调和成膏状，给予背部脱毛后的哮喘大鼠穴位敷贴；再以卵清白蛋白激发哮喘，观察哮喘大鼠的潜伏期；末次雾化吸入卵清白蛋白后，采血测定白介素-12、13的水平。结果 与哮喘模型组比较，防喘膏敷贴能延长哮喘大鼠的潜伏期；与正常对照组比较，哮喘模型组大鼠血清IL-12水平降低，IL-13水平升高；与哮喘模型组比较，防喘膏敷贴组及辅舒酮气雾剂组IL-12水平均升高，IL-13水平均降低；防喘膏敷贴组及辅舒酮气雾剂组IL-12、13水平差异无统计学意义。结论 防喘膏穴位敷贴能延长哮喘大鼠的哮喘潜伏期，降低哮喘大鼠血清IL-13水平，提高哮喘大鼠血清IL-12水平。 |
| 英文摘要: |
| Abstract Objective: Observe Fangchuangao effect on Bronchial Asthma rats and the content of IL-12 and IL-13 in rats.Methods:Grinding Ephedra,Chinese rhubarb,White Mustard Seed,Earthworm,asarum and folium pyrrosiae into fine powder,then mixing with ginger juice.Then applying it at points on the back of rats which have been moulted;then using Albumin Chicken Egg to stimulate asthma，then we can obserbe the incubation period change of asthma rats.After the last inhalation of Albumin Chicken Egg,determining the content of IL-12 and IL13 in rats.Results:Compared with the model group,Fangchuangao application can prolong the incubation period of bronchial Asthma rats.Compared with the normal group,the content of IL-12 in blood serum of model group was decreased and the content of IL-13 was increased;Compared with the model group,the content of IL-12 in blood serum of Fangchuangao group and Becotide group were increased and the content of IL-13 was decreased;The content of IL-12 and IL-13 in the Fangchuangao group and Becotide group were not markedly different.Conclusion:Fangchuangao application can prolong the incubation period of bronchial Asthma rats,increase the content of IL-12 in blood serum of bronchial Asthma rats and decrease the content of IL-13 in blood serum of bronchial Asthma rats. |
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