| 汪长健,杨关根,丁菁,廖秀军.帕瑞昔布钠和曲马多在肛周脓肿术中超前镇痛的效果比较[J].浙江中西医结合杂志,2014,24(10): |
| 帕瑞昔布钠和曲马多在肛周脓肿术中超前镇痛的效果比较 |
| Comparison of preemptive analgesia between parecoxib sodium and tramadol on the perianal abscess operation |
| 投稿时间：2014-01-22 修订日期：2014-08-20 |
| DOI： |
| 中文关键词: 帕瑞昔布钠 曲马多 镇痛 肛周脓肿 |
| 英文关键词:parecoxib sodium tramadol analgesia perianal abscess |
| 基金项目:2012杭州市科技局引导项目 |
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| 中文摘要: |
| 目的 比较帕瑞昔布钠和曲马多用于肛周脓肿术中超前镇痛的临床效果和不良反应。方法 选择90例需行肛周脓肿切排引流术的患者,随机分成两组,帕瑞昔布钠组(A组)和曲马多组(B组),每组各45例患者。A组于术前15min静脉注射帕瑞昔布钠40mg；B组于术前15min静脉注射2mg/kg,观察患者术后2h、3h、4h、6h、8h、12h、24h的疼痛视觉模拟评分(VAS)和身体舒适度评分(BCS),以及术后恶心、呕吐、呼吸抑制、心悸胸闷、头晕嗜睡、低血压等不良反应,并统计术后24h内镇痛药追加情况。结果 A组和B组在术后各时间点的VAS评分和BCS评分均无统计学差异(P＞0.05)；B组在恶心呕吐、头晕嗜睡和胸闷的发生率明显高于A组,差异有统计学意义(P＜0.05)。结论：帕瑞昔布钠与曲马多可明显减轻肛周脓肿术后的疼痛,二者均可用于肛周脓肿手术的超前镇痛,但帕瑞昔布钠的不良反应发生率明显低于曲马多。 |
| 英文摘要: |
| Objective To compare the effect of preemptive analgesia and the adverse effects between parecoxib sodium and tramadol in patients with perianal abscess operation. Methods 90 perianal abscess patients who needed operations were divided into two groups: parecoxib sodium group(group A, n=45), and tramadol group(group B, n=45). Group A were intravenously injected with 40mg parecoxib sodium, while group B were intravenously injected with 2mg/kg tramadol. Visal Analogue Scale(VAS) and Body Comfort Scale(BCS) were applied to measured the intensity of the pain at 2h、3h、4h、6h、8h、12h、24h after surgery; adverse effects like nausea, vomiting, respiratory depression, palpitation, chest distress, dizziness and drowsiness, hypotension were also recorded. In addition, analgesics used within 24h after operation was recorded too. Results No statistical differences were observed between goup A and group B in VAS and BCS at each time.(P ＞0.05), while the adverse effects such as nausea, vomiting chest distress,dizziness and drowsiness in group B were significantly high than that of group A(P ＜0.05). Conclusion Parecoxib sodium and tramadol can significantly reduce the post-operation analgesia of perianal abscess, both can be used as preemptive analgesia of perianal abscess patients. Moreover, parecoxib sodium had significantly lower incidence of adverse effects than tramadol. |
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