| 石莹.参附注射液对急性失血性休克患者减少红细胞输注量以及凝血功能的影响[J].浙江中西医结合杂志,2014,24(9): |
| 参附注射液对急性失血性休克患者减少红细胞输注量以及凝血功能的影响 |
| The effects of Shenfu injection in patients with hemorrhagic shock, by reducing the red blood cells transfusions, and ameliorating coagulation. |
| 投稿时间：2013-12-17 修订日期：2014-06-24 |
| DOI： |
| 中文关键词: 参附注射液 失血性休克 血流动力学 RBC输注量 |
| 英文关键词:Shenfu injection hemorrhagic shock hemodynamics RBCs transfusions |
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| 中文摘要: |
| 摘要：目的 观察参附注射液对失血性休克患者减少红细胞（RBC）输注量以及输血相关并发症的影响。方法 选取APACHEⅡ评分≥15分并且≤25分急性失血性休克患者60例，随机分为治疗组与对照组一、对照组二。三组均予常规止血早期液体复苏等治疗，对照组一设定血红蛋白（Hb）<60g/L为输血指征；对照组二Hb<80g/L为输血指征；治疗组应用参附注射液，同时设定以Hb<60g/L为输血指征。观察各组血管活性药物维持时间、ICU治疗天数、RBC输注量、6h和24h动脉血乳酸清除率、24h和72h凝血酶原时间（PT）。结果治疗组的血管活性药物维持时间、ICU治疗天数、RBC输注量、6小时以及24小时乳酸清除率、24小时以及72小时PT指标明显优于对照组一 (P<0.05或P<0.01)；在血管活性药物维持时间、6小时乳酸清除率上，治疗组与对照组二无明显差异（P>0.05），但在ICU治疗天数、RBC输注量、24小时乳酸清除率、24小时以及72小时PT治疗组优于对照组二（P<0.05或P<0.01）。结论 参附注射液能显著改善失血性休克患者的血流动力学状态，增加组织氧供，有效改善细胞氧代谢，从而减少失血性休克患者RBC输注量，改善凝血功能。 |
| 英文摘要: |
| Abstract :Objective Observe the effects of Shenfu injection in patients with hemorrhagic shock, reducing the red blood cells (RBCs) transfusions, and avoiding transfusion complications. Methods Sixty hemorrhagic shock patients were randomly assigned the treatment group, the control group 1 and the control group 2, whose APACHEⅡscore were in 15-25. The 3 groups accepted conventional hemostatic treatment and early fluid resuscitation. The indications of blood transfusion were Hb<60 g/L and Hb<80 g/L in the control groups 1 and 2, respectively. The treatment group used Shenfu injection, and the indications of blood transfusion were Hb<60 g/L. Three groups of patients were observed the time of using vasoactive drugs, the ICU stay days, RBC transfusions, 6h and 24h lactate clearance rate, 24h and 72h prothrombin time (PT). Results The time of using vasoactive drugs, the ICU stay days ,RBCs transfusions, 6h and 24h lactate clearance rate, 24h and 72h prothrombin time in the treatment group were superior to those in the control groups 1 (P<0.05 or P<0.01). The time of using vasoactive drugs and the 6h lactate clearance rate in the treatment group have no obvious difference with control group 2（P>0.05）.The ICU stay days , RBCs transfusions , the 24h lactate clearance rate , the 24h and 72h of PT in the treatment group were superior to those in the control groups 2 (P<0.05 or P<0.01). Conclusion Shenfu injection could significantly recover the hemodynamic status of patients with hemorrhagic shock by increasing tissue oxygen supply and effectively improving cellular oxygen metabolism. Furthermore, it reduced the patients RBCs transfusions and ameliorated coagulation. |
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