| 夏同伟,金国伟,王国强.参附注射液对腹腔镜胆囊切除术患者炎症细胞因子的影响*[J].浙江中西医结合杂志,2014,24(6): |
| 参附注射液对腹腔镜胆囊切除术患者炎症细胞因子的影响* |
| The effect of Shenfu Injection on inflammatory factors in patients undergoing laparoscopic cholecystectomy |
| 投稿时间：2013-10-09 修订日期：2013-10-14 |
| DOI： |
| 中文关键词: 参附注射液 腹腔镜胆囊切除术 血流动力学 炎症因子 |
| 英文关键词:Shenfu Injection Laparoscopic cholecystectomy Hemodynamics Inflammatory factor |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨参附注射液对腹腔镜胆囊手术(LC)患者围术期血流动力学及炎症因子浓度的影响。方法 行LC术患者64例,随机分为参附组与对照组各32例。参附组于麻醉诱导前给予参附注射液1 ml/kg静滴,对照组予等量生理盐水,两组其他处理相同。记录使用参附前(T0)、麻醉诱导前(T1)、气管插管后即刻(T2)、气腹1 min后(T3)、拔除气管导管即刻(T4)血流动力学。抽取T0、T4、术后6 h(T5)、术后24 h(T6)外周静脉血,ELISA法测定C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平。结果 参附组各时点MAP与HR与T0比较无明显差异,对照组T3的MAP与HR较T0有明显下降,显著低于参附组(P<0.05)。与T0比较,两组CPR、IL-6、TNF-α于T4时点开始升高,在T5时点升至最高点(P<0.01),T6时仍显著升高(P<0.05)。参附组在T5、T6时点CRP、IL-6、TNF-α明显低于对照组(P<0.01)。两组患者的手术时间、麻醉时间及术中失血量均无显著差异。结论 参附注射液能有效减少LC患者围术期炎症因子释放,维持血流动力学稳定,提高患者围术期安全。 |
| 英文摘要: |
| Objective To investigate effects of Shenfu Injection on hemodynamics and inflammatory factors in patients undergoing laparoscopic cholecystectomy (LC). Methods Sixty-four patients undergoing LC were divided into Shenfu group and control group (n=32). Shenfu group was intravenously dripped with Shenfu Injection (1 ml/kg) and control group was given saline before anesthesia. The intraoperative analgesia in both groups was preserved by intravenous injection of propofol and remifentanil. The hemodynamics of patients was recorded before giving Shenfu Injection (T0), anesthesia (T1), immediately after tracheal intubation (T2), 1 min after pneumoperitoneum (T3), and immediately after extubation (4). The serum C reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) at T0, T4, 6 h (T5) and 24 h (T6) after LC were measured using ELISA method. Results Mean arterial pressure (MAP) and heart rate (HR) in Shenfu group were no difference during the surgery. MAP and HR at T3 was significantly decreased in control group compared with Shenfu group (P<0.05). Compared with T0, CPR, IL-6, and TNF-α were all increased from T4, reached the peak at T5 (P<0.01), and even increased at T6 (P<0.05). The levels of serum CPR, IL-6, and TNF-α at T5 and T6 in Shenfu group were all lowed compared with control group (P<0.01). The operation time, duration of anesthesia, and operative bleeding in both groups were no significant difference. Conclusion Shenfu Injection was effective on inhibiting perioperative inflammatory factors and stabilizing hemodynamics, which was beneficial to the LC patients during the perioperative period. |
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