| 何丽清,张林.当归贝母苦参煎剂对实验性慢性细菌性前列腺炎
大鼠全血黏度的影响[J].浙江中西医结合杂志,2013,23(1):12-19 |
| 当归贝母苦参煎剂对实验性慢性细菌性前列腺炎
大鼠全血黏度的影响 |
| Effects of DANGGUIBEIMUKUSHEN Decoction on the Whole Blood Viscosity of Chronic Bacterial Pros?tatitic rats |
| 投稿时间：2012-08-10 |
| DOI： |
| 中文关键词: 慢性细菌性前列腺炎
当归贝母苦参煎剂
全血黏度 |
| 英文关键词:chronic bacterial prostatitis
DANGGUIBEIMUKUSHEN Decoction
whole blood viscosity |
| 基金项目:国家重点基础研究发展计划（“973”计划）资助项目（No.2010CB530604） |
|
| 摘要点击次数: 1286 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：观察当归贝母苦参煎剂对慢性细菌性前列腺炎（CBP）大鼠全血黏度的影响，探讨其
可能的作用机制。方法：70只雄性SD大鼠，随机分为空白对照组15只，模型组55只，制备CBP动
物模型，造模成功50只大鼠再随机分为模型组、诺氟沙星组、当归贝母苦参煎剂高、中、低剂量组，
每组10只。当归贝母苦参煎剂高、中、低剂量分别为1.1667g/mL、0.5833g/mL和0.2917g/mL，诺氟
沙星浓度为0.0093g/mL。术后第15天起用药，共用药4周。测定各组大鼠的全血黏度。结果：高、
中、低切变率时当归贝母苦参煎剂高剂量组大鼠全血黏度分别为（3.82±0.09）mPa·s、（4.41±0.30）
mPa·s和（10.18±0.97）mPa·s，与诺氟沙星组比较，差异有统计学意义（P＜0.05）。结论：当归贝母苦
参煎剂可以促进血液循环，改善药物在前列腺中的渗透及腺体分泌功能的恢复，这可能是当归贝
母苦参煎剂的作用机制之一。 |
| 英文摘要: |
| Objective: To investigate the effects of DANGGUIBEIMUKUSHEN(DGBMKS) Decoction on the whole
blood viscosity of chronic bacterial prostatitis(CBP)rats. Methods: A CBP model was established in SD rats and
were treated by high-(1.1667g/ml), medium-(0.5833g/ml), and low-dose(0.2917g/ml) of DGBMKS decoction and
norfloxacin(0.0093g/mL, western drug control) on postoperative day 15 for 4 weeks. The whole blood viscosity
was measured. Results：The whole blood viscosity significantly increased in CBP rats(P<0.01) and the increase
was ameliorated by the treatment of medium- and high-dose of DGBMKS decoction(P<0.05). The whole blood
viscosity was significantly lower after high-dose DGBMKS treatment than that after norflaxacin treatment(P<0.05).
Conclusion: DGBMKS decoction can lower the whole blood viscosity of CBP rats. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
