| 余泽兵,舒亦斌,雷慧慧.胃腺癌组织Naked1和MMP-9表达及其相关性研究[J].浙江中西医结合杂志,2013,23(1):9-11 |
| 胃腺癌组织Naked1和MMP-9表达及其相关性研究 |
| Correlation between Naked1 and Matrix Metalloproteinase 9 in Gastric Adenocarcinoma |
| 投稿时间：2012-07-02 |
| DOI： |
| 中文关键词: 胃腺癌
Naked1
MMP-9
免疫组化 |
| 英文关键词:gastric adenocarcinoma
Naked1
MMP-9
immunohistochemistry |
| 基金项目: |
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| 摘要点击次数: 1179 |
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| 中文摘要: |
| 目的：观察胃腺癌组织Naked1和MMP-9蛋白表达特征，探讨两者的关系及临床价值。方
法：选择97例胃腺癌术后留取的蜡块作为胃癌组，选择62例正常胃黏膜组织作为正常对照组，应
用免疫组织化学技术检测两组中Naked1和MMP-9蛋白表达，观察Naked1和MMP-9表达与临床
病理特征的相关性。结果：胃癌组 Naked1 蛋白表达阳性率明显低于正常对照组（P<0.01），
MMP-9蛋白表达阳性率明显高于正常对照组（P<0.01）。胃癌组Naked1和MMP-9蛋白表达与肿
瘤的临床分期、淋巴结转移、浸润深度、Ki67表达密切相关（P<0.05或P<0.01）；Naked1和MMP-9表
达具有负相关性（P<0.05），生存分析显示Naked1低表达、MMP-9高表达患者预后差。结论：胃腺
癌组织 Naked1 和 MMP-9 呈异常表达，两者对病变的进展具有重要作用，术后检测 Naked1 和
MMP-9表达可能对判断预后有一定价值。 |
| 英文摘要: |
| Objective: To explore the relationship between Naked1 and matrix metalloproteinase 9 (MMP-9) in gas?
tric adenocarcinoma and its potential role in prognosis. Methods: Specimens from gastric adenocarcinoma tissue
(n=97) and normal gastric tissue (n=62) were harvested. Expression of Naked1 and MMP-9 was determined by
using immunohistochemistry. Results: Compared with the normal gastric tissue, Naked1 expression was lower but
MMP-9 was higher in the gastric adenocarcinoma tissue. Naked1 and MMP-9 expression was closely related to
clinical stage of carcinoma, metastasis,infiltration, and Ki67(P<0.05 or P<0.01). Naked1 was negatively related to
MMP-9 (P<0.05). Survival analysis showed that lower expression of Naked1 and higher expression of MMP-9
was associated with poor prognosis. Conclusion: Naked1 is negatively correlated with MMP-9 in gastric adenocar?
cinoma and they may play a potential role in determining prognosis of gastric adenocarcinoma patients. |
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