| 张弘,马伟斌,雷澍,王灵聪,吴建浓,黄立权,吴艳春,智屹惠,朱美飞,江荣林.参附注射液对脓毒症模型大鼠心脏血流动力学的影响[J].浙江中西医结合杂志,2012,22(12):923-925 |
| 参附注射液对脓毒症模型大鼠心脏血流动力学的影响 |
| Effects of Shenfu Injection on Cardiac Hemodynamics in Rats with Sepsis |
| 投稿时间：2012-07-23 |
| DOI： |
| 中文关键词: 大鼠
脓毒症
参附注射液
血流动力学 |
| 英文关键词:rats
Sepsis
Shenfu Injection
hemodynamics |
| 基金项目:浙江省中医药科研基金计划项目（No.2008CA017） |
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| 中文摘要: |
| 目的：观察参附注射液对脓毒症大鼠心脏血流动力学的影响。方法：采用肓肠结扎穿孔
法制备腹腔感染脓毒症动物模型。80只SD大鼠随机分为假手术组、脓毒症组、参附注射液低、高
剂量组，每组20只。各实验组术后给予相应处理措施，观察术后6、18h各组的平均动脉压（MAP）、
心率（HR）、心脏收缩功能指标（LVDP和+dP/dt）、心脏舒张功能指标（LVEDP和-dP/dt）。结果：与假
手术组比较，脓毒症组术后6h HR显著升高（P<0.05），术后18h HR显著降低（P<0.01）；术后6h和
18h MAP、LVDP、+dP/dt、LVEDP、-dP/dt均显著下降（P均<0.01）。与脓毒症组比较，参附注射液低
剂量组术后6h MAP、HR差异无统计学意义（P均>0.05），术后18h MAP和HR显著升高（P<0.05）；
参附注射液高剂量组术后6h HR显著降低（P<0.05），术后18h HR和术后6、18h MAP均显著升高
（P均<0.01），参附注射液低、高剂量组术后6、18h的LVDP、+dP/dt、LVEDP、-dP/dt均显著升高（P<
0.05或<0.01）。结论：参附注射液可升高脓毒症大鼠的平均动脉压，改善其心脏收缩和舒张功能；
高剂量参附注射液作用更明显，并能改善心率。参附注射液能改善脓毒症大鼠心脏血流动力学的
作用强度与剂量有关。 |
| 英文摘要: |
| Objective: To observe the effects of Shenfu Injection(SF) on cardiac hemodynamics in rats with sepsis.
Methods: A total of 80 Sprague-Dawley(SD) rats were subjected to sepsis by cecal ligation and puncture(CLP)
and then were randomly divided into 4 groups: sham operation group(n=20), sepsis group(n=20), Low-SF group(n=
20) and High-SF group(n=20). Mean arterial pressure (MAP), heart rate (HR), heart systolic functional parameters
(LVDP and +dP/dt), heart diastolic functional parameters (LVEDP and -dP/dt) of each group were recorded in 6
h and 18 h
after the surgery and then compared. Results: Compared with the sham group, HR in sepsis group
increased significantly in 6h after surgery (P<0.05), but significantly decreased in 18 h after surgery(P<0.01); and
MAP, LVDP, +dP/dt, LVEDP, and -dP/dt in sepsis group all dramatically decreased in 6h and 18 h after surgery
(all P<0.01). Compared with sepsis group, Low-SF group had similar MAP and HR in 6h after surgery, but ele?
vated MAP and HR in 18h after surgery（all P>0.05); High-SF group had lower HR in 6h after surgery (P<0.05)
and increased HR in 18h and increased MAP in 6h and 18h after surgery（all P<0.01）;and both SF groups had
increased LVDP, +dP/dt, LVEDP, and -dP/dt in 6h and 18h after surgery（P<0.05 or 0.01）. Conclusion: SF can
increase MAP to different extent in septic rats. In addition, SF can improve cardiac systolic and diastolic func?
tion. These results were more obvious in High-SF group. These effects may be proportional to the dose of Shen?
fu Injection. |
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