| 李晓燕,朱晓芙,朱长玲,邱晓晓,程泾.慢盆消炎方对慢性子宫内膜炎模型大鼠IL-2、
MMP-2及TIMP-2的影响[J].浙江中西医结合杂志,2012,22(10):762-764 |
| 慢盆消炎方对慢性子宫内膜炎模型大鼠IL-2、
MMP-2及TIMP-2的影响 |
| Effects of Manpenxiaoyan Decocion on the Expression of IL-2, MMP-2, and TIMP-2 in Chronic Endo?metritis Rats |
| 投稿时间：2012-04-05 |
| DOI： |
| 中文关键词: 大鼠 慢性子宫内膜炎 慢盆消炎方 IL-2 MMP-2 TIMP-2 |
| 英文关键词:rats Manpenxiaoyan decoction chronic endometritis IL-2 MMP-2 TIMP-2 |
| 基金项目: |
|
| 摘要点击次数: 1096 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：观察慢盆消炎方对慢性子宫内膜炎（CE）模型大鼠IL-2、MMP-2及TIMP-2的影
响。方法：采用混合菌株联合支原体接种法制作慢性子宫内膜炎大鼠模型，给予慢盆消炎方灌胃
治疗，观察大鼠子宫及内膜组织病理改变，检测血清IL-2水平及子宫组织中基质金属蛋白酶-2
（MMP-2）、基质金属蛋白酶抑制剂-2（TIMP-2）的表达差异。结果：慢盆消炎方能改善慢性子宫内
膜炎模型大鼠子宫的组织损害，提高血清IL-2 含量，降低子宫内膜组织MMP-2 表达及调节
MMP-2/TIMP-2 比值。结论：慢盆消炎方对CE 模型大鼠具有显著治疗作用，减少细胞外基质
（ECM）和血管基底膜降解是其作用机制。 |
| 英文摘要: |
| Objective: To investigate the therapeutic effect and mechanisms of Manpenxiaoyan Decoction (MPXYD)
on rat with chronic endometritis. Methods: Rat models with chronic endometritis were established by inoculating
admixed bacteria into endometrium and mycoplasma into vagina. Seventy SD model rats were randomly divided in?
to 7 groups: blank control group，model group，Fulechongji group，doxycycline group，and low-,medium-,and
high-dose MPXYD groups,10 in each. Each group was intragastrically given the corresponding agents. Pathologi?
cal changes of the endometrium were observed. The serum level of IL-2 and matrix metalloproteinase-2
(MMP-2) and tissue inhibitors of meralloproteinase-2(TIMP-2) in endometrial tissue were determined. Results:
MPXYD reduced inflammatory cell infiltration in endometrium, elevated IL-2,and reduced the expression of
MMP-2 and the ratio of MMP-2 to TIMP-2. Conclusion: MPXYD may cure chronic endometritis by reducing in?
flammation and degrading basement membrane of blood vessels. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
