| 李慧娥.食管鳞癌组织p33/ING1和PTEN蛋白表达的相关性研究[J].浙江中西医结合杂志,2012,22(9):694-702 |
| 食管鳞癌组织p33/ING1和PTEN蛋白表达的相关性研究 |
| Study on the Relationship Between p33/ING1 and PTEN Protein in Esophageal Cancer Tissue |
| 投稿时间：2012-04-19 |
| DOI： |
| 中文关键词: 食管鳞癌 p33/ING1 PTEN 抑癌基因 |
| 英文关键词:esophageal squamous cell carcinoma p33/ING1 PTEN tumor suppressor gene |
| 基金项目: |
|
| 摘要点击次数: 1202 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的： 探讨食管癌组织p33/ING1和PTEN蛋白表达及其相关性。方法： 采用免疫组织化学
技术联合检测凋亡促进因子P33/ING1、 PTEN基因在58例食管癌大体标本中的表达情况。结果：
p33/ING1和PTEN蛋白从正常黏膜—不典型增生—浸润癌渐进性表达减低， 在正常黏膜与浸润癌
组织表达差异有统计学意义 （P<0.05， P<0.01）。食管癌组织PTEN与p33/ING1表达呈正相关。结
论： p33/ING1和PTEN基因的失活 （或缺失） 及表达下调在食管鳞癌的发生、 分化及浸润转移过程中
起重要作用。可能为临床食管癌早期诊断、 相关治疗及预后研究提供新的手段。 |
| 英文摘要: |
| Objective：To investigate the expression of p33/ING1 and PTEN proteins in esophageal cancer tis?
sues. Method: P33/ING1 and PTEN protein as apoptosis-promoting factors were detected in gross specimens
from 58 patients with esophageal cancer by immunohistochemistry. Results: The expression of p33/ING1 and
PTEN protein from normal mucosa to dysplasia to invasive carcinoma was gradually decreased, with a significant
difference between normal mucosa tissue and invasive carcinoma(P<0.05 or P<0.01). A correlation was noted be?
tween the level of PTEN protein and the expression of p33/ING1 in esophageal cancer tissue. Conclusion: p33/
ING1 and PTEN gene inactivation (or loss) and decreased protein expression play an important role in the occur?
rence, differentiation, invasion, and metastasis of esophageal squamous cell carcinoma. They may be valuable for
the diagnosis, treatment, and predicting prognosis of esophageal cancer. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
