| 郑绪阳.EGCG对食饵性肥胖幼鼠模型早期动脉病变的干预作用[J].浙江中西医结合杂志,2012,22(9):678-680 |
| EGCG对食饵性肥胖幼鼠模型早期动脉病变的干预作用 |
| Intervention of Epigallocatechin-3 Gallate on Early Arterial Disease in Over-feeding Obese Young SDRats |
| 投稿时间：2012-03-19 |
| DOI： |
| 中文关键词: 肥胖幼鼠模型 表没食子儿茶素没食子酸酯 水通道蛋白7 早期动脉粥样硬化 |
| 英文关键词:young obese rat model epigallocatechin-3 gallate aquaporin 7 early atherosclerosis |
| 基金项目:杭州市医药卫生科技计划项目 （No.2008B005） |
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| 中文摘要: |
| 目的： 观察表没食子儿茶素没食子酸酯 （EGCG） 对肥胖幼鼠模型动脉病变和水通道蛋白
7mRNA表达的干预作用。方法:通过过度喂养建立食饵性肥胖幼鼠模型， 将出生第3天的雄性SD
大鼠72只随机分为对照组、 模型组、 EGCG低剂量组和EGCG高剂量组， 每组18只， HE染色观察各
组腹主动脉早期动脉病变， 同时运用real-time PCR测定脂肪和腹主动脉组织AQP-7mRNA表达。
结果： EGCG低剂量可降低腹主动脉平滑肌中粥样斑块形成， EGCG高剂量可有效改善腹主动脉早
期动脉粥样硬化形成， 下调脂肪组织和腹主动脉AQP-7mRNA表达水平 （P<0.01）。结论： EGCG可
能通过下调肥胖大鼠脂肪组织和腹主动脉AQP-7mRNA表达水平而起到减肥和改善早期动脉粥
样硬化的作用。 |
| 英文摘要: |
| Objective：To investigate the effect of epigallocatechin-3 gallate(EGCG) on early arterial disease and
the expression of aquaporin 7(AQP-7)mRNA in obese young rats.Methods: Obese model was induced by
over-feeding in young SD rats.A total of 72 3-day young rats were randomly divided into control group， model
group,low-dose EGCG group,and high-dose EGCG group (18 in each). Early abdominal aortic artery lesions were
observed by HE staining. AQP-7 mRNA expression in fat and abdominal aorta tissues was determined by Re?
al-Time PCR.Results: Lose-dose EGCG reduced the formation of atherosclerotic plaques in the abdominal aorta
smooth muscles; high-dose EGCG effectively improved attenuated early atherosclerosis of the abdominal aorta and
at the same time downregulated the AQP-7 mRNA expression in fat tissue and abdominal aorta as compared to
the model group(P<0.01).Conclusions: EGCG may control the weight and attenuate early atherosclerosis of the ab?
dominal aorta by decreasing the level of AQP-7 mRNA in adipose tissue and abdominal aorta in young obese rats. |
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