| 羊燕群,潘 锋,赵 瑾,徐建军,马志杭,陈建永,刘 敏.健胃合剂对功能性消化不良模型大鼠胃肠动力和
血清胆碱酯酶活性的影响[J].浙江中西医结合杂志,2012,22(8):592-594 |
| 健胃合剂对功能性消化不良模型大鼠胃肠动力和
血清胆碱酯酶活性的影响 |
| Influence of Jian-wei Decoction on Gastrointestinal Motility and Serum Cholinesterase of Rats with Func?tional Dyspepsia |
| 投稿时间：2011-11-23 |
| DOI： |
| 中文关键词: 大鼠 功能性消化不良 胃肠动力 血清胆碱酯酶 健胃合剂 多潘立酮 |
| 英文关键词:rats functional dyspepsia gastrointestinal motility serum cholinesterase Jian-wei decoction dom?
peridone |
| 基金项目:杭州市科技局重点专科专项资助项目 （No.20091233Q23） |
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| 中文摘要: |
| 目的： 观察健胃合剂对功能性消化不良 （FD） 模型大鼠胃肠动力状态和血清胆碱酯酶的影
响。方法： 将32只SD大鼠随机分为正常组、 模型组、 健胃合剂组和多潘立酮组， 每组8只。采用适
度夹尾刺激法复制FD大鼠模型， 分别予健胃合剂、 多潘立酮治疗， 检测各组大鼠胃残留率与胃肠
碳末推进率和血清胆碱酯酶水平。结果： 模型组、 健胃合剂组、 多潘立酮组大鼠体质量明显低于正
常组 （P<0.05）； 健胃合剂组、 多潘立酮组大鼠胃内残留率低于模型组 （P<0.05）， 胃肠碳末推进率高
于模型组 （P<0.05）； 健胃合剂组与多潘立酮组大鼠胃内残留率、 胃肠推进率比较差异无统计学意义
（P>0.05）； 各组大鼠血清胆碱酯酶水平比较差异无统计学意义 （P>0.05）； 胃肠碳末推进率与血清胆
碱酯酶水平呈正相关 （r=0.34， P<0.05）。结论： 健胃合剂对FD模型大鼠胃排空、 蠕动功能下降的改
善作用与多潘立酮相似。 |
| 英文摘要: |
| Objective: To evaluate the effect of Jian-wei decoction on the gastrointestinal motility and serum cho?
linesterase of rats with functional dyspepsia. Method:SD rats were randomly divided into normal group,model
group,Chinese-Medicine group(CG),and West-Medicine group (WG),8 in each. The rats were injured by ring
clamp to be FD except the normal group. Rats in CG were treated with Jian-wei decoction,and those in WG
were treated with domperidone. Gastric residual rate and advance rate of carbon in small intestine was taken,as
well as serum cholinesterase was tested at the end of the study. Results: Mean body weights of rats in the mod?
el group,CG, and WG were higher that of the normal group(P<0.05). Gastric residual rates of CG and WG were
lower than that of the model group(P<0.05), while advance rates of carbon in CG and WG were higher(P<0.05).
No significant difference in the 2 index was noted between CG and WG(P>0.05). The level of serum cholinester?
ase did not differ among the 4 groups(P>0.05). A positive correlation of advance rate of carbon with serum cho?
linesterase was seen(r=0.34， P<0.05). Conclusion: Jian-wei decoction had a similar effect of promoting gastrointes?
tinal motility with domperidone. |
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