许 莉,侯 群,佟丽妍.乌司他汀对兔脑出血脑保护作用的实验研究[J].浙江中西医结合杂志,2012,22(5):339-341 |
乌司他汀对兔脑出血脑保护作用的实验研究 |
Effect of Ulinastatin on Cerebral Protection during Rabbit Intracerebral Hemorrhage |
投稿时间:2011-10-28 |
DOI: |
中文关键词: 新西兰兔 脑出血 乌司他汀 STM vWF NO |
英文关键词:New Zealand rabbits intracerebral hemorrhage ulinastatin soluble thrombomodulin von Wille?brand factor nitric oxide |
基金项目:天普研究基金项目 (No.01200919) |
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中文摘要: |
目的: 通过观察脑出血兔血清可溶性血栓调节蛋白 (STM)、 血管假血友病因子 (vWF)、 一
氧化氮 (NO) 含量变化, 探讨乌司他汀的脑保护作用。方法: 40只新西兰大白兔随机分为正常对照
组、 模型组、 乌司他汀1天组和乌司他汀3天组, 每组10只。用自体血法制备兔脑出血模型, 应用
Ellisa法测定各组兔血清STM、 vWF、 NO含量。结果: 与正常对照组比较, 模型组STM、 vWF和NO含
量显著增高 (P<0.05)。乌司他汀1天组、 3天组的STM、 vWF和NO均低于模型组 (P<0.05), 乌司他
汀3天组STM、 vWF和NO含量与乌司他汀1天组比较, 差异无统计学意义 (P>0.05)。结论: 乌司他
汀抑制STM、 vWF和NO生成, 从而减轻脑出血兔脑细胞的损伤, 具有脑保护作用。 |
英文摘要: |
Objective: To explore the effect of ulinastatin on the contents of soluble thrombomodulin(STM), von
Willebrand factor(vWF), and nitric oxide(NO) in rabbits with intracerebral hemorrhage(ICH). Methods: Rabbit
ICH model was prepared with autologous blood. Forty New Zealand white rabbits were randomly divided into 4
groups of 10 each, including normal control group, sham operation group, ulinastatin 1-day group, and ulina?
statin 3-day group. A double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used to as?
sess the levels of rabbit STM, vWF, and NO. Results: Compared with the normal control group, the levels of
STM, vWF, and NO in the sham group were significantly higher (P<0.05). Compared with the sham operation
group, the STM, vWF, and NO levels were lower in the ulinastatin 1-day and 3-day groups (P<0.05). No signifi?
cant difference in these parameters was noted between the ulinastatin 1-day group and the ulinastatin 3-day
group (P>0.05). Conclusion: Ulinastatin can cut down the generation of STM, vWF, and NO to less cerebral
damage during rabbit ICH. |
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