| 那万秋,李建华,陈 科,夏青春.舒肝解郁胶囊联合舍曲林治疗老年脑卒中后抑郁疗效及其对神经功能缺损影响的对照研究[J].浙江中西医结合杂志,2012,22(4):245-247 |
| 舒肝解郁胶囊联合舍曲林治疗老年脑卒中后抑郁疗效及其对神经功能缺损影响的对照研究 |
| Comparative Observation on Efficacy of Shuganjieyu Capsules Combined with Sertraline in Treatment of Aged Poststroke Depression |
| 投稿时间：2011-09-08 |
| DOI： |
| 中文关键词: 老年人 脑卒中后抑郁 神经功能缺损 舒肝解郁胶囊 舍曲林 |
| 英文关键词:aged poststroke depression neurological deficit Shuganjieyu capsule sertraline |
| 基金项目: |
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| 中文摘要: |
| 目的： 观察舒肝解郁胶囊联合舍曲林治疗老年脑卒中后抑郁的临床疗效及其对神经功能
缺损的影响。方法： 80例老年脑卒中后抑郁患者随机分为研究组 （舒肝解郁胶囊联合舍曲林组） 41
例和对照组 （舍曲林组） 39例， 观察8周。于治疗前、 治疗第2、 4、 8周末分别采用汉密尔顿抑郁量表
（HAMD）、 汉密尔顿焦虑量表 （HAMA）、 副反应量表 （TESS） 评定疗效和副反应， 采用中国脑卒中患
者临床神经功能缺损评分标准 （CSS） 评定对神经功能缺损的影响， 并进行实验室监测。结果： 至研
究终点， 研究组和对照组治疗老年脑卒中后抑郁有效率分别为82.9%、 61.5％， 研究组优于对照组
（P<0.05）； 研究组与对照组HAMD、 HAMA分数均显著低于治疗前 （P<0.05）， 两组间比较， 研究组评
分均低于对照组， 差异均有统计学意义 （均P<0.05）。治疗后两组均未出现严重不良反应， 研究组
TESS评分与对照组相当 （P>0.05）。治疗后两组CSS评分显著低于治疗前 （P<0.05）， 研究组CSS评
分显著低于对照组 （P<0.05）。结论： 舒肝解郁胶囊联合舍曲林治疗老年脑卒中后抑郁症疗效和对
神经功能缺损改善优于单用舍曲林， 安全性好。 |
| 英文摘要: |
| Objective： To observe the clinical efficacy， adverse reactions， and recovery of neural function of Shugan?
jieyu capsules combined with sertraline in treating aged poststroke depression. Methods： The randomized con?
trolled tria1 was conducted in 41 aged patients of the study （Shuganjieyu capsules combined with sertraline）
group and 39 aged patients of the control (sertraline) group. The therapeutic efficacy, adverse reactions, and neu?
rological function defect were evaluated with scores by Hamilton Depression Scale, Hamilton Anxiety Scale, Treat?
ment Emergent Symptoms Scale， and Chinese Scale of Clinical Neurologic Deficit（CSS）before and in 2nd， 4th，
8th weeks after treatment， respectively. Results： At the end of study, the effective rates of treating aged post?
stroke depression in the study and the control groups were 81.9% and 61.5%, respectively, with a significant dif?
ference between them （P<0.05） . The scores of HAMD and HAMA were significantly decreased in both groups af?
ter treatment （P<0.05） and the scores of HAMD and HAMA was significantly lower in the study group than
that in the control group （P<0.05） . No severe adverse effect was found in both groups. The score of TESS was
not statistically different between the 2 groups （P>0.05） . The scores of CSS were also reduced in both groups af?
ter treatment （P<0.05）， with a lower score in the study group as compared to that in the control group （P<
0.05） . Conclusions： Shuganjieyu capsules combined with sertraline can improve depressive symptoms and promote
recovery of neurological function in aged patients with poststroke depression, which is superior than single use of
sertraline. |
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