| 周玲玲,林琼琼,周伶俐,祁旦巳,赵志光.姜黄素对非酒精性脂肪肝家兔血脂及肝组织PPAR-γ 水平的影响[J].浙江中西医结合杂志,2012,22(1):7-10 |
| 姜黄素对非酒精性脂肪肝家兔血脂及肝组织PPAR-γ 水平的影响 |
| Effect of Curcumin on Serum Lipid and Expression of Peroxisome Proliferators -activated Receptor γ in theNon-alcoholic Fatty Liver Disease Rabbits |
| 投稿时间：2011-05-11 |
| DOI： |
| 中文关键词: 非酒精性脂肪肝 家兔 过氧化物酶体增殖物激活受体γ 胰岛素抵抗 姜黄素 |
| 英文关键词:non-alcoholic fatty liver disease rabbits peroxisome proliferators-activated receptor γ insulin resistance
curcumin
7 |
| 基金项目:浙江省温州市科技局科研项目（No.Y20100340） |
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| 摘要点击次数: 1581 |
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| 中文摘要: |
| 目的：观察姜黄素对非酒精性脂肪肝病（NAFLD）家兔血脂、胰岛素抵抗指数及肝组织过
氧化物酶体增殖物激活受体γ（PPAR-γ）水平的影响。方法：34 只家兔制备NAFLD 模型，随机分为
姜黄素组和NAFLD 组各17 只，均予基础饲料喂养，姜黄素组家兔每天按200mg/kg 体质量给予姜
黄素混悬液灌胃, NAFLD 组给予相同容积的生理盐水， 治疗1 个月。治疗前后检测血甘油三酯
（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C） 、高密度脂蛋白胆固醇（HDL-C）、空腹血糖
（FBG）、空腹胰岛素（FNS），并计算胰岛素抵抗（HOMA-IR）指数，免疫组织化学法测定肝组织
PPAR-γ 蛋白表达，观察肝组织病理学变化。结果：治疗后姜黄素组血浆TG、TC、LDL-C 显著降低
（P<0.01），HDL-C 显著升高（P<0.05），胰岛素抵抗指数显著降低（P<0.05），PPAR-γ 蛋白表达显著
升高（P<0.05），肝脂肪变性明显好转。结论：姜黄素可降低NAFLD 模型家兔血脂、肝脏脂质合成与
聚积，对NAFLD 有治疗作用。 |
| 英文摘要: |
| To observe the effects of curcumin on serum lipids and the expression of peroxisome proliferatorsactivated
receptor γ (PPAR-γ)in the non-alcoholic fatty liver disease (NAFLD) rabbits. Methods: Thirty-four rabbits established
non-alcoholic fatty liver disease model were randomly divided into 2 experimental groups: control group(17 animals)
and treatment group (17 animals). Both groups were fed standard diet for 1 month. Additionally, the treatment group
received oral curcumin at dose of 200 mg·kg-1·d-1 and the control group received an oral curcumin-free sodium chloride
solution daily during the experiment. Blood samples were collected from before and after experiment. Serum was separated
and used for the assessment of triglyceride(TG), total cholesterol (TC), LDL-C, HDL-C, fasting blood glucose（FBG）, fasting
insulin（FNS）, and HOMA-IR index was calculated. The expression of PPARγ protein was measured by immunohistochemistry,
and pathological alterations in the liver were examined. Results: Compared with the control group, the treatment
group had significantly decreased serum TG,TC and LDL-C (P<0.01) , and increased HDL-C(P<0.05). Curcumin also
decreased HOMA-IR (P<0.05) and increased the expression of PPARγ protein (P<0.05). The fatty degeneration of the
liver was significantly improved. Conclusion: Curcumin can degrade lipid synthesis and accumulation in blood serum and
the liver of NAFLD rabbits. Therefore, curcumin can prevent and cure NAFLD. |
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